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学科主题: Biochemistry & Molecular Biology; Pharmacology & Pharmacy
题名: The Interleukin-18 Inhibitory Activities of Echinocystic Acid and its Saponins from Impatiens pritzellii var. hupehensis
作者: Zhou, XF ; Tang, L ; Zhang, P ; Zhao, XY ; Pi, HF ; Zhang, YH ; Ruan, HL ; Liu, Y ; Wu, JZ
通讯作者: zpeng_1979@163.com
关键词: Echinocystic Acid ; Impatiens pritzellii var. hupehensis ; Interleukin-18
刊名: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
发表日期: 2009
卷: 64, 期:40669, 页:369-372
收录类别: sci
部门归属: [Zhou, Xue-Feng; Zhang, Peng; Pi, Hui-Fang; Zhang, Yong-Hui; Ruan, Han-Li; Wu, Ji-Zhou] Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Pharmaceut Sci, Hubei Key Lab Nat Med Chem & Evaluat Resources, Wuhan 430030, Peoples R China; [Zhou, Xue-Feng; Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Tang, Lan] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China; [Zhao, Xiao-Ya] Hubei Entry Exit Inspect & Quarantine Bur, Wuhan 430022, Peoples R China
项目归属: LMB
摘要: Echinocystic acid (1), an echinocystic acid saponin, 2, and four of its ester saponins, 3-6, obtained from the active fraction of Impatiens pritzellii var. hupehensis, an traditional Chinese medicine for rheumatoid arthritis, were investigated for their effects on lipopolysaccharide (LPS)-induced interleukin (IL)-18 in human peripheral blood mononuclear cells. Three of them,1, 2 and 6, showed obvious activity to inhibit the production of IL-18, especially the ester saponins with a sugar chain at C-28, 6. Structure-activity relationships are discussed in brief.
原文出处: 查看原文
WOS记录号: WOS:000268826700011
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5086
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Zhou, XF; Tang, L; Zhang, P; Zhao, XY; Pi, HF; Zhang, YH; Ruan, HL; Liu, Y; Wu, JZ.The Interleukin-18 Inhibitory Activities of Echinocystic Acid and its Saponins from Impatiens pritzellii var. hupehensis,ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES,2009,64(40669):369-372
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