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学科主题: Biochemistry & Molecular Biology; Nutrition & Dietetics
题名: An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells
作者: Zhou, XF ; Tang, L ; Liu, YH
通讯作者: zhou-xuefeng@hotmail.com ; tanglan_tongji@hotmail.com
关键词: Soya-cerebrosides ; Mixture of cerebrosides ; Interleukin-18 ; Cytotoxicity ; Peripheral blood mononuclear cells
刊名: LIPIDS
发表日期: 2009
卷: 44, 期:8, 页:759-763
收录类别: sci
部门归属: [Tang, Lan] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China; [Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 mu M, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug.
原文出处: 查看原文
WOS记录号: WOS:000268301900009
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5094
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Zhou, XF; Tang, L; Liu, YH.An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells,LIPIDS,2009,44(8):759-763
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文件名: An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells .pdf
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