An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells
Zhou, XF; Tang, L; Liu, YH; zhou-xuefeng@hotmail.com; tanglan_tongji@hotmail.com
2009
发表期刊LIPIDS
ISSN0024-4201
卷号44期号:8页码:759-763
摘要An isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 mu M, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug.
部门归属[Tang, Lan] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China; [Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
关键词Soya-cerebrosides Mixture Of Cerebrosides Interleukin-18 Cytotoxicity Peripheral Blood Mononuclear Cells
学科领域Biochemistry & Molecular Biology ; Nutrition & Dietetics
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收录类别sci
资助项目LMB
WOS记录号WOS:000268301900009
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5094
专题中科院海洋生物资源可持续利用重点实验室
通讯作者zhou-xuefeng@hotmail.com; tanglan_tongji@hotmail.com
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Zhou, XF,Tang, L,Liu, YH,et al. An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells[J]. LIPIDS,2009,44(8):759-763.
APA Zhou, XF,Tang, L,Liu, YH,zhou-xuefeng@hotmail.com,&tanglan_tongji@hotmail.com.(2009).An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells.LIPIDS,44(8),759-763.
MLA Zhou, XF,et al."An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells".LIPIDS 44.8(2009):759-763.
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