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An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells
Zhou, XF; Tang, L; Liu, YH; zhou-xuefeng@hotmail.com; tanglan_tongji@hotmail.com
2009
Source PublicationLIPIDS
ISSN0024-4201
Volume44Issue:8Pages:759-763
AbstractAn isomeric mixture of two cerebrosides, soya-cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya-cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)-induced interleukin (IL)-18 in PBMC were studied. The MC at concentrations of 10 and 1 mu M, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL-18 secretion. Because of this effect of modulating the cellular immune response, soya-cerebrosides I and II were considered to be the active substances of this ethno drug.
Department[Tang, Lan] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China; [Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
KeywordSoya-cerebrosides Mixture Of Cerebrosides Interleukin-18 Cytotoxicity Peripheral Blood Mononuclear Cells
Subject AreaBiochemistry & Molecular Biology ; Nutrition & Dietetics
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Indexed Bysci
Funding ProjectLMB
WOS IDWOS:000268301900009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/5094
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorzhou-xuefeng@hotmail.com; tanglan_tongji@hotmail.com
Recommended Citation
GB/T 7714
Zhou, XF,Tang, L,Liu, YH,et al. An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells[J]. LIPIDS,2009,44(8):759-763.
APA Zhou, XF,Tang, L,Liu, YH,zhou-xuefeng@hotmail.com,&tanglan_tongji@hotmail.com.(2009).An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells.LIPIDS,44(8),759-763.
MLA Zhou, XF,et al."An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide-Induced Release of IL-18 from Human Peripheral Blood Mononuclear Cells".LIPIDS 44.8(2009):759-763.
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