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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity
作者: Li, YL ; Yang, XW ; Li, SM ; Shen, YH ; Zeng, HW ; Liu, XH ; Tang, J ; Zhang, WD
通讯作者: yangxw76@163.com ; wdzhangy@hotmail.com
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2009
卷: 72, 期:6, 页:1065-1068
收录类别: sci
部门归属: [Li, Yong-Li; Yang, Xian-Wen; Shen, Yun-Heng; Zeng, Hua-Wu; Liu, Xiao-Hua; Tang, Jian; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen; Li, Su-Mei] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
项目归属: LMB
摘要: Six new triterpenes (neoabieslactones A-F, 1-6) and 17 known compounds were isolated from the aerial parts of Abies chensiensis. The structures of the new triterpenes were proposed by 1D and 2D NMR spectroscopy. Compound 1 was confirmed structurally by X-ray crystallography. In a bioassay against LPS-induced NO production in RAW264.7 macrophages, three compounds, neoabieslactone E (5), (12R,13R)-8,12-epoxy-14-labden-13-ol (7), and manool (8), exhibited IC50 values of 9.1, 1.9, and 9.6 mu g/mL, respectively.
原文出处: 查看原文
WOS记录号: WOS:000267432600015
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5096
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, YL; Yang, XW; Li, SM; Shen, YH; Zeng, HW; Liu, XH; Tang, J; Zhang, WD.Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity,JOURNAL OF NATURAL PRODUCTS,2009,72(6):1065-1068
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