Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity
Li, YL; Yang, XW; Li, SM; Shen, YH; Zeng, HW; Liu, XH; Tang, J; Zhang, WD; yangxw76@163.com; wdzhangy@hotmail.com
2009
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号72期号:6页码:1065-1068
摘要Six new triterpenes (neoabieslactones A-F, 1-6) and 17 known compounds were isolated from the aerial parts of Abies chensiensis. The structures of the new triterpenes were proposed by 1D and 2D NMR spectroscopy. Compound 1 was confirmed structurally by X-ray crystallography. In a bioassay against LPS-induced NO production in RAW264.7 macrophages, three compounds, neoabieslactone E (5), (12R,13R)-8,12-epoxy-14-labden-13-ol (7), and manool (8), exhibited IC50 values of 9.1, 1.9, and 9.6 mu g/mL, respectively.
部门归属[Li, Yong-Li; Yang, Xian-Wen; Shen, Yun-Heng; Zeng, Hua-Wu; Liu, Xiao-Hua; Tang, Jian; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen; Li, Su-Mei] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
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收录类别sci
资助项目LMB
WOS记录号WOS:000267432600015
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被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5096
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yangxw76@163.com; wdzhangy@hotmail.com
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Li, YL,Yang, XW,Li, SM,et al. Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1065-1068.
APA Li, YL.,Yang, XW.,Li, SM.,Shen, YH.,Zeng, HW.,...&wdzhangy@hotmail.com.(2009).Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity.JOURNAL OF NATURAL PRODUCTS,72(6),1065-1068.
MLA Li, YL,et al."Terpenoid Constituents of Abies chensiensis with Potential Anti-inflammatory Activity".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1065-1068.
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