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Antimalarial flavonol glycosides from Euphorbia hirta
Liu, Y; Murakami, N; Ji, H; Abreu, P; Zhang, S; yonghongliu@scsio.ac.cn
2007
发表期刊PHARMACEUTICAL BIOLOGY
ISSN1388-0209
卷号45期号:4页码:278-281
摘要Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC50 values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.
部门归属Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China; Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan; Univ Nova Lisboa, REQUIMTE, Dept Quim, FCT, Caparica, Portugal
关键词Afzelin Antimalarial Cytotoxicity Euphorbia Hirta Myricitrin Quercitrin
学科领域Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
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收录类别sci
资助项目广东省海洋药物重点实验室
WOS记录号WOS:000247132400005
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5232
专题广东省海洋药物重点实验室
通讯作者yonghongliu@scsio.ac.cn
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GB/T 7714
Liu, Y,Murakami, N,Ji, H,et al. Antimalarial flavonol glycosides from Euphorbia hirta[J]. PHARMACEUTICAL BIOLOGY,2007,45(4):278-281.
APA Liu, Y,Murakami, N,Ji, H,Abreu, P,Zhang, S,&yonghongliu@scsio.ac.cn.(2007).Antimalarial flavonol glycosides from Euphorbia hirta.PHARMACEUTICAL BIOLOGY,45(4),278-281.
MLA Liu, Y,et al."Antimalarial flavonol glycosides from Euphorbia hirta".PHARMACEUTICAL BIOLOGY 45.4(2007):278-281.
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