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学科主题: Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
题名: Antimalarial flavonol glycosides from Euphorbia hirta
作者: Liu, Y ; Murakami, N ; Ji, H ; Abreu, P ; Zhang, S
通讯作者: yonghongliu@scsio.ac.cn
关键词: afzelin ; antimalarial ; cytotoxicity ; euphorbia hirta ; myricitrin ; quercitrin
刊名: PHARMACEUTICAL BIOLOGY
发表日期: 2007
卷: 45, 期:4, 页:278-281
收录类别: sci
部门归属: Chinese Acad Sci, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China; Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan; Univ Nova Lisboa, REQUIMTE, Dept Quim, FCT, Caparica, Portugal
项目归属: 广东省海洋药物重点实验室
摘要: Bioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC50 values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.
原文出处: 查看原文
WOS记录号: WOS:000247132400005
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5232
Appears in Collections:广东省海洋药物重点实验室_期刊论文

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Recommended Citation:
Liu, Y; Murakami, N; Ji, H; Abreu, P; Zhang, S.Antimalarial flavonol glycosides from Euphorbia hirta,PHARMACEUTICAL BIOLOGY,2007,45(4):278-281
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