SCSIO OpenIR  > 广东省海洋药物重点实验室
Antimalarial flavonol glycosides from Euphorbia hirta
Liu, Y; Murakami, N; Ji, H; Abreu, P; Zhang, S;
AbstractBioassay-guided fractionation of the MeOH extracts of Euphorbia hirta Linn (Euphorbiaceae) aerial parts led to the isolation of flavonol glycosides afzelin (1), quercitrin (2), and myricitrin (3), whose structures were established by MS and NMR analysis. Compounds 1-3 showed proliferation inhibition of Plasmodium falciparum, with IC50 values of 1.1, 4.1, 5.4 mu g/mL, repectively. On the other hand, they exhibited little cytotoxic property against human epidermoid carcinoma KB 3-1 cells.
DepartmentChinese Acad Sci, Guangdong Key Lab Marine Mat Med, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China; Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan; Univ Nova Lisboa, REQUIMTE, Dept Quim, FCT, Caparica, Portugal
KeywordAfzelin Antimalarial Cytotoxicity Euphorbia Hirta Myricitrin Quercitrin
Subject AreaPlant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
Indexed Bysci
Funding Project广东省海洋药物重点实验室
WOS IDWOS:000247132400005
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Liu, Y,Murakami, N,Ji, H,et al. Antimalarial flavonol glycosides from Euphorbia hirta[J]. PHARMACEUTICAL BIOLOGY,2007,45(4):278-281.
APA Liu, Y,Murakami, N,Ji, H,Abreu, P,Zhang, S,& flavonol glycosides from Euphorbia hirta.PHARMACEUTICAL BIOLOGY,45(4),278-281.
MLA Liu, Y,et al."Antimalarial flavonol glycosides from Euphorbia hirta".PHARMACEUTICAL BIOLOGY 45.4(2007):278-281.
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