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学科主题: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy
题名: Alkaloids from the Stem Bark of Micromelum falcatum
作者: Luo, XM ; Qi, SH ; Yin, H ; Gao, CH ; Zhang, S
通讯作者: zhsimd@scsio.ac.cn
关键词: Micromelum falcatum ; alkaloid ; quinoldione ; quinolinone
刊名: CHEMICAL & PHARMACEUTICAL BULLETIN
发表日期: 2009
卷: 57, 期:6, 页:600-602
收录类别: sci
部门归属: [Luo, Xiong Ming; Qi, Shu Hua; Yin, Hao; Gao, Cheng Hai; Zhang, Si] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Materia Med, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Xiong Ming] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Xiong Ming; Zhang, Si] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
项目归属: 广东省海洋药物重点实验室
摘要: Two new quinoldione alkaloids, methyl 2-(3-hydroxy-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl)acetate (1) and 3-hydroxy-1-methyl-3-(2-oxopropyl)quinoline-2,4(1H,3H)-dione (2), and two quinolinone alkaloids previously synthesized but first isolated as natural products, N-methylflindersine (3) and 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (4), were isolated from the stem bark of Micromelum falcatum, together with the known N-methylswietenidine-B (5). Their structures were established mainly on the basis of 1D- and 2D-NMR techniques. All compounds were evaluated for toxicity towards brine shrimp larvae, and 3 showed strong toxicity with an LD50 value of 1.39 mu g/ml.
原文出处: 查看原文
WOS记录号: WOS:000266480600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5326
Appears in Collections:广东省海洋药物重点实验室_期刊论文

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Recommended Citation:
Luo, XM; Qi, SH; Yin, H; Gao, CH; Zhang, S.Alkaloids from the Stem Bark of Micromelum falcatum,CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(6):600-602
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文件名: Alkaloids from the Stem Bark of Micromelum falcatum.pdf
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