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Alkaloids from the Stem Bark of Micromelum falcatum
Luo, XM; Qi, SH; Yin, H; Gao, CH; Zhang, S; zhsimd@scsio.ac.cn
2009
发表期刊CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN0009-2363
卷号57期号:6页码:600-602
摘要Two new quinoldione alkaloids, methyl 2-(3-hydroxy-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl)acetate (1) and 3-hydroxy-1-methyl-3-(2-oxopropyl)quinoline-2,4(1H,3H)-dione (2), and two quinolinone alkaloids previously synthesized but first isolated as natural products, N-methylflindersine (3) and 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (4), were isolated from the stem bark of Micromelum falcatum, together with the known N-methylswietenidine-B (5). Their structures were established mainly on the basis of 1D- and 2D-NMR techniques. All compounds were evaluated for toxicity towards brine shrimp larvae, and 3 showed strong toxicity with an LD50 value of 1.39 mu g/ml.
部门归属[Luo, Xiong Ming; Qi, Shu Hua; Yin, Hao; Gao, Cheng Hai; Zhang, Si] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Materia Med, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Xiong Ming] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Luo, Xiong Ming; Zhang, Si] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
关键词Micromelum Falcatum Alkaloid Quinoldione Quinolinone
学科领域Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
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收录类别sci
资助项目广东省海洋药物重点实验室
WOS记录号WOS:000266480600011
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5326
专题广东省海洋药物重点实验室
通讯作者zhsimd@scsio.ac.cn
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Luo, XM,Qi, SH,Yin, H,et al. Alkaloids from the Stem Bark of Micromelum falcatum[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2009,57(6):600-602.
APA Luo, XM,Qi, SH,Yin, H,Gao, CH,Zhang, S,&zhsimd@scsio.ac.cn.(2009).Alkaloids from the Stem Bark of Micromelum falcatum.CHEMICAL & PHARMACEUTICAL BULLETIN,57(6),600-602.
MLA Luo, XM,et al."Alkaloids from the Stem Bark of Micromelum falcatum".CHEMICAL & PHARMACEUTICAL BULLETIN 57.6(2009):600-602.
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