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Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice
Wu, JL; Wu, QP; Huang, JM; Chen, R; Cai, M; Tan, JB; microwjl@yahoo.com
2007
发表期刊PHYSIOLOGICAL RESEARCH
ISSN0862-8408
卷号56期号:2页码:213-220
摘要L-malate, a tricarboxylic acid cycle (TCA) intermediate, plays an important role in transporting NADH from cytosol to mitochondria for energy production and may be involved in the beneficial effects of improving physical stamina. In the present study, we investigated the effects of L-malate on the performance of forced swimming time and blood biochemical parameters related to fatigue-blood urea nitrogen (BUN), glucose (Glc), creatine kinase (CK), total protein (TP) and lactic acid (LA). To investigate the effects of L-malate on the malate-aspartate shuttle and energy metabolism in mice, the activities of enzymes related to the malate-aspartate shuttle were measured. L-malate was orally administered to mice continuously for 30 days using a feeding atraumatic needle. The swimming time was increased by 26.1 % and 28.5 %, respectively, in the 0.210 g/kg and 0.630 g/kg L-malate-treated group compared with the control group. There were no differences in the concentrations of Glc, BUN and TP between the L-malate-treated groups and the control groups. However, the levels of CK were significantly decreased in the L-malate-treated groups. The results predict a potential benefit of L-malate for improving physical stamina and minimizing muscle damage during swimming exercise. The activities of cytosolic and mitochondrial malate dehydrogenase were significantly elevated in the L-malate-treated group compared with the control group. These enzymatic activities may be useful indicators for evaluating changes affecting the malate-aspartate shuttle and energy metabolism in the liver of mice.
部门归属Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China; Ctr Dis Control & Prevent, Dept Toxicol, Guangzhou 510020, Guangdong, Peoples R China; Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
关键词L-malate Tricarboxylic Acid Cycle Malate-aspartate Shuttle Malate Dehydrogenase Aspartate Dehydrogenase Mitochondria
学科领域Physiology
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收录类别sci
资助项目海洋生物
WOS记录号WOS:000246657500009
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5342
专题海洋生物
通讯作者microwjl@yahoo.com
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Wu, JL,Wu, QP,Huang, JM,et al. Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice[J]. PHYSIOLOGICAL RESEARCH,2007,56(2):213-220.
APA Wu, JL.,Wu, QP.,Huang, JM.,Chen, R.,Cai, M.,...µwjl@yahoo.com.(2007).Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice.PHYSIOLOGICAL RESEARCH,56(2),213-220.
MLA Wu, JL,et al."Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice".PHYSIOLOGICAL RESEARCH 56.2(2007):213-220.
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