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Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg
Wu, ZC; Chen, YC; Li, DL; Zhang, WM
2009
发表期刊PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2
页码278-281
摘要Nodulisporium sp. A4, an endophytic fungus isolated from the traditional Chinese medicinal plant Aquilaria sinensis (Lour.) Gilg, had been fermented and the culture broth and mycelia were extracted with organic solvent respectively. CCK-8 assay was used to test the cytotoxic effects of the extracts, and the results showed that both the extracts exhibited cytotoxicity on NCI-H460 and SF-268 cell lines in vitro. The culture broth and mycelia extracts were roughly fractionated by Si-gel column chromatography, 20 and 16 fractions were obtained respectively. All the fractions were submitted to cytotoxicity assay. Fractions Fr7, Fr13 (from the culture broth extract) and Fr6', Fr9', Fr13' (from the mycelia extract) were found to be the main potential active parts. This result provided the basis for the fractionation of cytotoxic natural products in the next studies, as well as giving the possibility to develop and utilise the medicinal endophytic fungi from the A. sinensis.
部门归属[Wu Zheng-chao] CAS, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
关键词Aquilaria Sinensis Endophytic Fungus NoduliSp.rium Sp. Extract Cytotoxicity
学科领域Integrative & Complementary Medicine ; Medicine, General & Internal ; Pharmacology & Pharmacy
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收录类别sci
资助项目海洋生物
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5382
专题海洋生物
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Wu, ZC,Chen, YC,Li, DL,et al. Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg[J]. PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2,2009:278-281.
APA Wu, ZC,Chen, YC,Li, DL,&Zhang, WM.(2009).Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg.PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2,278-281.
MLA Wu, ZC,et al."Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg".PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 (2009):278-281.
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