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学科主题: Integrative & Complementary Medicine; Medicine, General & Internal; Pharmacology & Pharmacy
题名: Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg
作者: Wu, ZC ; Chen, YC ; Li, DL ; Zhang, WM
关键词: Aquilaria sinensis ; endophytic fungus ; Nodulisporium sp. ; extract ; cytotoxicity
刊名: PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2
发表日期: 2009-01-01
页: 278-281
收录类别: sci
部门归属: [Wu Zheng-chao] CAS, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: 海洋生物
摘要: Nodulisporium sp. A4, an endophytic fungus isolated from the traditional Chinese medicinal plant Aquilaria sinensis (Lour.) Gilg, had been fermented and the culture broth and mycelia were extracted with organic solvent respectively. CCK-8 assay was used to test the cytotoxic effects of the extracts, and the results showed that both the extracts exhibited cytotoxicity on NCI-H460 and SF-268 cell lines in vitro. The culture broth and mycelia extracts were roughly fractionated by Si-gel column chromatography, 20 and 16 fractions were obtained respectively. All the fractions were submitted to cytotoxicity assay. Fractions Fr7, Fr13 (from the culture broth extract) and Fr6', Fr9', Fr13' (from the mycelia extract) were found to be the main potential active parts. This result provided the basis for the fractionation of cytotoxic natural products in the next studies, as well as giving the possibility to develop and utilise the medicinal endophytic fungi from the A. sinensis.
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5382
Appears in Collections:海洋生物_期刊论文

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Wu, ZC; Chen, YC; Li, DL; Zhang, WM.Study on Cytotoxic Activity of Extracts of an Endophytic Fungus Nodulisporium sp A4 Isolated from Aquilaria sinensis (Lour.) Gilg,PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2,2009,():278-281
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