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学科主题: Toxicology
题名: Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum
作者: Lin, ZF ; Zhang, WH ; Wang, LS ; Yu, HX ; Wu, CD
关键词: malononitrile ; Photobacterium phosphoreum ; p-nitrobenzaldehyde ; synergistic toxicity ; toxicodynamic interactions ; toxicokinetic interactions
刊名: TOXICOLOGY MECHANISMS AND METHODS
发表日期: 2003
卷: 13, 期:4, 页:241-245
收录类别: sci
部门归属: Chinese Acad Sci, S China Sea Inst Oceanol, Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China; Natl Key Res Stn Trop Marine Biol, Sanya, Peoples R China; Nanjing Univ, State Key Lab Pollut Control & Resources Reuse, Sch Environm, Nanjing 210008, Peoples R China; S China Univ Technol, Sch Pulp & Environm Engn, Guangzhou, Peoples R China
项目归属: LED
摘要: In this study the mechanism of synergistic toxicity between malononitrile and p-nitrobenzaidehyde was revealed by examining their toxicodynamic and toxicokinetic interactions. The investigation of the toxicodynamic interactions focused on the interactions among malononitrile, p-nitrobenzaldehyde, and luciferase, and found that malononitrile does not induce luciferase to bind p-nitrobenzaidehyde. This result suggested that the synergistic toxicity does not arise from toxicodynamic interactions. Further research on toxicokinetic interactions compared the amounts of p-nitrobenzaidehyde being transported from the water phase to the biotic phase in two circumstances-in the presence of malononitrile and in its absence. The results of this research indicated that in the presence of malononitrile, more p-nitrobenzaldehyde is transported, and it is the increased amount of p-nitrobenzaidehyde that leads to the synergistic toxicity of malononitrile and p-nitrobenzaldehyde.
原文出处: 查看原文
WOS记录号: WOS:000186699700001
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5535
Appears in Collections:热带海洋环境动力实验室(LTO)_期刊论文

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Lin, ZF; Zhang, WH; Wang, LS; Yu, HX; Wu, CD.Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum,TOXICOLOGY MECHANISMS AND METHODS,2003,13(4):241-245
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