Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum
Lin, ZF; Zhang, WH; Wang, LS; Yu, HX; Wu, CD
2003
发表期刊TOXICOLOGY MECHANISMS AND METHODS
ISSN1537-6524
卷号13期号:4页码:241-245
摘要In this study the mechanism of synergistic toxicity between malononitrile and p-nitrobenzaidehyde was revealed by examining their toxicodynamic and toxicokinetic interactions. The investigation of the toxicodynamic interactions focused on the interactions among malononitrile, p-nitrobenzaldehyde, and luciferase, and found that malononitrile does not induce luciferase to bind p-nitrobenzaidehyde. This result suggested that the synergistic toxicity does not arise from toxicodynamic interactions. Further research on toxicokinetic interactions compared the amounts of p-nitrobenzaidehyde being transported from the water phase to the biotic phase in two circumstances-in the presence of malononitrile and in its absence. The results of this research indicated that in the presence of malononitrile, more p-nitrobenzaldehyde is transported, and it is the increased amount of p-nitrobenzaidehyde that leads to the synergistic toxicity of malononitrile and p-nitrobenzaldehyde.
部门归属Chinese Acad Sci, S China Sea Inst Oceanol, Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China; Natl Key Res Stn Trop Marine Biol, Sanya, Peoples R China; Nanjing Univ, State Key Lab Pollut Control & Resources Reuse, Sch Environm, Nanjing 210008, Peoples R China; S China Univ Technol, Sch Pulp & Environm Engn, Guangzhou, Peoples R China
关键词Malononitrile Photobacterium Phosphoreum P-nitrobenzaldehyde Synergistic Toxicity Toxicodynamic Interactions Toxicokinetic Interactions
学科领域Toxicology
URL查看原文
收录类别sci
资助项目LED
WOS记录号WOS:000186699700001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5535
专题热带海洋环境国家重点实验室(LTO)
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Lin, ZF,Zhang, WH,Wang, LS,et al. Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum[J]. TOXICOLOGY MECHANISMS AND METHODS,2003,13(4):241-245.
APA Lin, ZF,Zhang, WH,Wang, LS,Yu, HX,&Wu, CD.(2003).Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum.TOXICOLOGY MECHANISMS AND METHODS,13(4),241-245.
MLA Lin, ZF,et al."Mechanism of the synergistic toxicity of malononitrile and p-nitrobenzaldehyde with Photobacterium phosphoreum".TOXICOLOGY MECHANISMS AND METHODS 13.4(2003):241-245.
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