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学科主题: Chemistry, Medicinal; Chemistry, Organic
题名: Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.
作者: Huang, XC ; Zhao, D ; Guo, YW ; Wu, HM ; Lin, LP ; Wang, ZH ; Ding, H ; Lin, YS
通讯作者: ywguo@mail.shcnc.ac.cn
关键词: dinoflagellate ; Amphidinium sp ; lingshuiol ; antitumor
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2004
卷: 14, 期:12, 页:3117-3120
收录类别: sci
部门归属: Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China; Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
项目归属: LED
摘要: A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC50 of 0.21 and 0.23 muM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000221776800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5637
Appears in Collections:热带海洋环境动力实验室(LTO)_期刊论文

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Recommended Citation:
Huang, XC; Zhao, D; Guo, YW; Wu, HM; Lin, LP; Wang, ZH; Ding, H; Lin, YS.Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004,14(12):3117-3120
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