Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.
Huang, XC; Zhao, D; Guo, YW; Wu, HM; Lin, LP; Wang, ZH; Ding, H; Lin, YS; ywguo@mail.shcnc.ac.cn
2004
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号14期号:12页码:3117-3120
摘要A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC50 of 0.21 and 0.23 muM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
部门归属Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Peoples R China; Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
关键词Dinoflagellate Amphidinium Sp Lingshuiol Antitumor
学科领域Chemistry, Medicinal ; Chemistry, Organic
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收录类别sci
资助项目LED
WOS记录号WOS:000221776800021
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5637
专题热带海洋环境国家重点实验室(LTO)
通讯作者ywguo@mail.shcnc.ac.cn
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GB/T 7714
Huang, XC,Zhao, D,Guo, YW,et al. Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2004,14(12):3117-3120.
APA Huang, XC.,Zhao, D.,Guo, YW.,Wu, HM.,Lin, LP.,...&ywguo@mail.shcnc.ac.cn.(2004).Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,14(12),3117-3120.
MLA Huang, XC,et al."Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14.12(2004):3117-3120.
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