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Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals
Lin, ZF; Du, JW; Yin, KD; Wang, LS; Yu, HX; lzhifen@yahoo.com
2004
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume54Issue:11Pages:1691-1701
AbstractAccording to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures. (C) 2003 Elsevier Ltd. All rights reserved.
DepartmentChinese Acad Sci, S China Sea Inst Oceanol, Key Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China; Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resources Reuse, Nanjing 210093, Peoples R China
KeywordMechanism Of Concentration Addition Toxicity Nonpolar Narcotic Chemical Polar Narcotic Chemical Reactive Chemical
Subject AreaEnvironmental Sciences
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Indexed Bysci
Funding ProjectLED
WOS IDWOS:000189132000011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/5663
Collection热带海洋环境国家重点实验室(LTO)
Corresponding Authorlzhifen@yahoo.com
Recommended Citation
GB/T 7714
Lin, ZF,Du, JW,Yin, KD,et al. Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals[J]. CHEMOSPHERE,2004,54(11):1691-1701.
APA Lin, ZF,Du, JW,Yin, KD,Wang, LS,Yu, HX,&lzhifen@yahoo.com.(2004).Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.CHEMOSPHERE,54(11),1691-1701.
MLA Lin, ZF,et al."Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals".CHEMOSPHERE 54.11(2004):1691-1701.
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