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学科主题: Environmental Sciences
题名: Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals
作者: Lin, ZF ; Du, JW ; Yin, KD ; Wang, LS ; Yu, HX
通讯作者: lzhifen@yahoo.com
关键词: mechanism of concentration addition toxicity ; nonpolar narcotic chemical ; polar narcotic chemical ; reactive chemical
刊名: CHEMOSPHERE
发表日期: 2004
卷: 54, 期:11, 页:1691-1701
收录类别: sci
部门归属: Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China; Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resources Reuse, Nanjing 210093, Peoples R China
项目归属: LED
摘要: According to the toxicity mechanism of the individual chemicals, the concentration addition toxicity mechanism is revealed for nonpolar-narcotic-chemical mixtures, polar-narcotic-chemical mixtures and reactive-chemical mixtures, respectively. For nonpolar-narcotic-chemical mixtures, the partitioning of individual chemicals from water to biophase was determined, and the result shows that their concentration additive effect results from no competitive partitioning among individual chemicals. For polar-narcotic-chemical mixtures, their toxicity are contributed by two factors (the total baseline toxicity and the hydrogen bond donor activity of individual chemicals), and it is the concentration additive effect for either of these two factors that leads to their concentration addition toxicity. In addition, the interactions between the reactive chemicals and the biological macromolecules are discussed thoroughly. The results suggest that the net effect of these interactions is zero, and it is this zero net effect that leads to the concentration addition toxicity mechanism for reactive-chemical mixtures. (C) 2003 Elsevier Ltd. All rights reserved.
原文出处: 查看原文
WOS记录号: WOS:000189132000011
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5663
Appears in Collections:热带海洋环境动力实验室(LTO)_期刊论文

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Lin, ZF; Du, JW; Yin, KD; Wang, LS; Yu, HX.Mechanism of concentration addition toxicity: they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals,CHEMOSPHERE,2004,54(11):1691-1701
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文件名: Mechanism of concentration addition toxicity they are different for nonpolar narcotic chemicals, polar narcotic chemicals and reactive chemicals.pdf
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