中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 热带海洋环境国家重点实验室(LTO)  > 期刊论文
学科主题: Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications; Pharmacology & Pharmacy
题名: Prediction of the toxicological joint effects between cyanogenic toxicants and aldehydes to Photobacterium phosphoreum
作者: Lin, ZF ; Niu, XJ ; Wu, C ; Yin, KD ; Cai, ZP
通讯作者: lzhifen@yahoo.com
关键词: the toxicological joint effect ; cyanogenic toxicants ; aldehydes ; chemical-chemical interaction ; QSAR ; Photobacterium phosphoreum
刊名: QSAR & COMBINATORIAL SCIENCE
发表日期: 2005
卷: 24, 期:3, 页:354-363
收录类别: sci
部门归属: Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Trop Marine Environm Dynam, Guangzhou 510301, Peoples R China; Chinese Acad Fishery Sci, E China Sea Fisheries Res Inst, Key Lab Marine & Estuarine Fisheries, Shanghai 200090, Peoples R China; S China Univ Technol, Sch Environm Sci & Engn, Guangzhou 510641, Peoples R China; Chinese Acad Sci, S China Sea Inst Oceanol, Dept Appl Marine Biol, Guangzhou 510301, Peoples R China
项目归属: LED
摘要: In this study, a general approach is proposed that predicts the toxicological effects, to Photobacterium phosphoreum, of cyanogenic toxicants in combination with aldehydes. Forty binary mixtures containing an aldehyde and a cyanogenic toxicant were examined. The observed results indicate that the toxicological joint effects are different (additive, synergistic, or antagonistic) from each other, and the differences depend on chemical-chemical interactions between the cyanogenic toxicants and the aldehydes. Analysis of the chemical-chemical interactions reveals that there are two characteristics of individual chemicals that contribute to the joint effects: one is the charge of the carbon atom in the -CHO group of aldehydes and the other is the charge of the carbon atom (C*) in the carbochain of cyanogenic toxicants. Based on these two contributors to toxicity, a quantitative structure-activity relationship (QSAR) model can be derived, namely M=0.367-0.811 sigma(p)-6.704 C* where r(2)=0.868, SE=0.232, F=121.769, P=0.000, M is the sum of toxic units; sigma(p) is the Hammett Constant and is used to evaluate the charge of the carbon atom in the -CHO of aldehydes; C* is the charge of the carbon atom in the carbochain of cyanogenic toxicants. Application of this model to the eight other related mixtures demonstrates the consistency between the predicted and observed toxicities, with r(2)=0.888, SE=0.223, F=45.562 at P=0.000. This prediction capability convinces us that the QSAR model provides a general approach to prediction of the joint toxicological joint effects of cyanogenic toxicants and aldehydes to Photobacterium phosphoreum.
WOS记录号: WOS:000228947600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/5721
Appears in Collections:热带海洋环境动力实验室(LTO)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Prediction of the toxicological joint effects between cyanogenic toxicants and aldehydes to Photobacterium phosphoreum.pdf(245KB)----开放获取--View Download

Recommended Citation:
Lin, ZF; Niu, XJ; Wu, C; Yin, KD; Cai, ZP.Prediction of the toxicological joint effects between cyanogenic toxicants and aldehydes to Photobacterium phosphoreum,QSAR & COMBINATORIAL SCIENCE,2005,24(3):354-363
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lin, ZF]'s Articles
[Niu, XJ]'s Articles
[Wu, C]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lin, ZF]‘s Articles
[Niu, XJ]‘s Articles
[Wu, C]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Prediction of the toxicological joint effects between cyanogenic toxicants and aldehydes to Photobacterium phosphoreum.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace