Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China
Zhang, QW; Su, XB; Gong, ST; Zeng, QY; Zhu, B; Wu, ZH; Peng, T; Zhang, CY; Zhou, R; Zhang_whu@yahoo.com.cn; zhou3218@yahoo.com
2006
发表期刊JOURNAL OF GENERAL VIROLOGY
ISSN0022-1317
卷号87期号:Part 6页码:1531-1541
摘要Human adenovirus type 3 (HAdV-3) is a causative agent of acute respiratory disease, which is prevalent throughout the world, especially in Asia. Here, the complete genome sequences of two field strains of HAdV-3 (strains GZ1 and GZ2) isolated from children with acute respiratory infection in southern China are reported (GenBank accession nos DQ099432 and DQ105654, respectively). The genomes were 35 273 by (GZ1) and 35 269 by (GZ2) and both had a G+C content of 51 mol%. They shared 99% nucleotide identity and the four early and five late regions that are characteristic of human adenoviruses. Thirty-nine protein- and two RNA-coding sequences were identified in the genome sequences of both strains. Protein pX had a predicted molecular mass of 8.3 kDa in strain GZ1; this was lower (7-6 kDa) in strain GZ2. Both strains contained 10 short inverted repeats, in addition to their inverted terminal repeats (111 bp). Comparative whole-genome analysis revealed 93 mismatches and four insertions/deletions between the two strains. Strain GZ1 infection produced a typical cytopathic effect, whereas strain GZ2 did not; non-synonymous substitutions in proteins of GZ2 may be responsible for this difference.
部门归属Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China; Cuangzhou Childrens Hosp, Cent Lab, Guangzhou 510120, Peoples R China; Chinese Acad Sci, LED, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China
学科领域Biotechnology & Applied Microbiology ; Virology
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收录类别sci
资助项目LED
WOS记录号WOS:000238167400012
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/5795
专题热带海洋环境国家重点实验室(LTO)
通讯作者Zhang_whu@yahoo.com.cn; zhou3218@yahoo.com
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Zhang, QW,Su, XB,Gong, ST,et al. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China[J]. JOURNAL OF GENERAL VIROLOGY,2006,87(Part 6):1531-1541.
APA Zhang, QW.,Su, XB.,Gong, ST.,Zeng, QY.,Zhu, B.,...&zhou3218@yahoo.com.(2006).Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China.JOURNAL OF GENERAL VIROLOGY,87(Part 6),1531-1541.
MLA Zhang, QW,et al."Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China".JOURNAL OF GENERAL VIROLOGY 87.Part 6(2006):1531-1541.
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