Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis
其他题名mannual of IR1
Zhang, QB; Li, HX; Li, SM; Zhu, YG; Zhang, GT; Zhang, HB; Zhang, WJ; Shi, R; Zhang, CS; czhang2006@gmail.com
2012
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号14期号:24页码:6142-6145
产权排序产权排序
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摘要The P450 enzyme XiaM was identified as a candidate to form the C-24 carboxyl group in xiamycin A (1). Alteration of medium composition led to the discovery of four new compounds from the Delta xiaM and the Delta xiaK (encoding an aromatic ring hydroxylase) mutants. Biotransformation experiments revealed that XiaM was capable of converting a methyl group to a carboxyl group through diol and aldehyde intermediates.; description.abstract
部门归属[Zhang, Qingbo; Li, Huixian; Li, Sumei; Zhu, Yiguang; Zhang, Guangtao; Zhang, Haibo; Zhang, Wenjun; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Qingbo] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Shi, Rong] Univ Laval, Dept Biochimie Microbiol & Bioinformat, PROTEO & IBIS, Quebec City, PQ G1V 0A6, Canada
学科领域Chemistry, Organic
资助者国科图 ; 国科图 ; 国科图 ; 国科图
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收录类别sci
语种英语
资助项目LMB
资助者国科图 ; 国科图 ; 国科图 ; 国科图
WOS记录号WOS:000312564500007
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9728
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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GB/T 7714
Zhang, QB,Li, HX,Li, SM,et al. Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis[J]. ORGANIC LETTERS,2012,14(24):6142-6145.
APA Zhang, QB.,Li, HX.,Li, SM.,Zhu, YG.,Zhang, GT.,...&czhang2006@gmail.com.(2012).Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis.ORGANIC LETTERS,14(24),6142-6145.
MLA Zhang, QB,et al."Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis".ORGANIC LETTERS 14.24(2012):6142-6145.
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