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学科主题: Cell Biology
题名: Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies
作者: Sun, Y ; Fu, YG ; Li, YX ; Xu, AL
通讯作者: lssxal@mail.sysu.edu.cn
关键词: alternative polyadenylation ; genome-wide profiling technologies ; gene expression regulation
刊名: JOURNAL OF MOLECULAR CELL BIOLOGY
发表日期: 2012-01-01
卷: 4, 期:6, 页:352-361
部门归属: [Sun, Yu; Fu, Yonggui; Li, Yuxin; Xu, Anlong] Sun Yat Sen Univ, Higher Educ Mega Ctr,State Key Lab Biocontrol, Coll Life Sci,Natl Engn Ctr S China Sea Marine Bi, Dept Biochem,Guangdong Prov Key Lab Pharmaceut Fu, Guangzhou 510006, Guangdong, Peoples R China
项目归属: LMB
摘要: Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods. In this review, we focus on the recent technological development of APA analyses on a genome-wide scale, as well as the impact of APA switches on a number of critical biological processes in animals, including cell proliferation, differentiation, and oncogenic transformation. With the highly enlarged scope of genome-wide APA analyses, the APA regulations of various biological processes have increasingly become a new paradigm for the regulation of gene transcription and translation.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9734
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Sun, Y; Fu, YG; Li, YX; Xu, AL.Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies,JOURNAL OF MOLECULAR CELL BIOLOGY,2012,4(6):352-361
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文件名: Genome-wide alternative polyadenylation.pdf
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