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Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies
Sun, Y; Fu, YG; Li, YX; Xu, AL;
AbstractAlternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability, translation, and translocation in cells. However, genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods. In this review, we focus on the recent technological development of APA analyses on a genome-wide scale, as well as the impact of APA switches on a number of critical biological processes in animals, including cell proliferation, differentiation, and oncogenic transformation. With the highly enlarged scope of genome-wide APA analyses, the APA regulations of various biological processes have increasingly become a new paradigm for the regulation of gene transcription and translation.
Department[Sun, Yu; Fu, Yonggui; Li, Yuxin; Xu, Anlong] Sun Yat Sen Univ, Higher Educ Mega Ctr,State Key Lab Biocontrol, Coll Life Sci,Natl Engn Ctr S China Sea Marine Bi, Dept Biochem,Guangdong Prov Key Lab Pharmaceut Fu, Guangzhou 510006, Guangdong, Peoples R China
KeywordAlternative Polyadenylation Genome-wide Profiling Technologies Gene Expression Regulation
Subject AreaCell Biology
Funding ProjectLMB
Document Type期刊论文
Recommended Citation
GB/T 7714
Sun, Y,Fu, YG,Li, YX,et al. Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2012,4(6):352-361.
APA Sun, Y,Fu, YG,Li, YX,Xu, AL,& alternative polyadenylation in animals: insights from high-throughput technologies.JOURNAL OF MOLECULAR CELL BIOLOGY,4(6),352-361.
MLA Sun, Y,et al."Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies".JOURNAL OF MOLECULAR CELL BIOLOGY 4.6(2012):352-361.
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