Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
Zhou, X; Huang, HB; Chen, YC; Tan, JH; Song, YX; Zou, JH; Tian, XP; Hua, Y; Ju, JH; jju@scsio.ac.cn
2012
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:12页码:2251-2255
摘要A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 mu g/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC50 values ranging from 0.38 to 0.52 mu M.
部门归属[Zhou, Xiao; Huang, Hongbo; Song, Yongxiang; Tian, Xinpeng; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Zhou, Xiao; Hua, Yan] SW Forestry Univ, Kunming 650224, Peoples R China; [Chen, Yuchan] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China; [Tan, Jiaheng] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; [Zou, Jianhua] Peking Union Med Coll, Beijing 100050, Peoples R China; [Zou, Jianhua] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种英语
资助项目LMB
WOS记录号WOS:000312823300031
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9736
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
推荐引用方式
GB/T 7714
Zhou, X,Huang, HB,Chen, YC,et al. Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(12):2251-2255.
APA Zhou, X.,Huang, HB.,Chen, YC.,Tan, JH.,Song, YX.,...&jju@scsio.ac.cn.(2012).Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652.JOURNAL OF NATURAL PRODUCTS,75(12),2251-2255.
MLA Zhou, X,et al."Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652".JOURNAL OF NATURAL PRODUCTS 75.12(2012):2251-2255.
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