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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652
作者: Zhou, X ; Huang, HB ; Chen, YC ; Tan, JH ; Song, YX ; Zou, JH ; Tian, XP ; Hua, Y ; Ju, JH
通讯作者: jju@scsio.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2012
卷: 75, 期:12, 页:2251-2255
部门归属: [Zhou, Xiao; Huang, Hongbo; Song, Yongxiang; Tian, Xinpeng; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Zhou, Xiao; Hua, Yan] SW Forestry Univ, Kunming 650224, Peoples R China; [Chen, Yuchan] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China; [Tan, Jiaheng] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China; [Zou, Jianhua] Peking Union Med Coll, Beijing 100050, Peoples R China; [Zou, Jianhua] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
项目归属: LMB
摘要: A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 mu g/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC50 values ranging from 0.38 to 0.52 mu M.
语种: 英语
WOS记录号: WOS:000312823300031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9736
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Zhou, X; Huang, HB; Chen, YC; Tan, JH; Song, YX; Zou, JH; Tian, XP; Hua, Y; Ju, JH.Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652,JOURNAL OF NATURAL PRODUCTS,2012,75(12):2251-2255
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文件名: Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide.pdf
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