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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum
作者: Sun, YL ; He, F ; Liu, KS ; Zhang, XY ; Bao, J ; Wang, YF ; Nong, XH ; Xu, XY ; Qi, SH
通讯作者: shuhuaqi@scsio.ac.cn
关键词: Penicillium oxalicum SCSGAF 0023 ; Meripilaceae family ; dihydrothiophene-condensed chromone ; cytotoxicity
刊名: PLANTA MEDICA
发表日期: 2012
卷: 78, 期:18, 页:1957-1961
部门归属: [Sun, Yu-Lin; He, Fei; Zhang, Xiao-Yong; Bao, Jie; Nong, Xu-Hua; Xu, Xin-Ya; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Kai-Sheng; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China; [Sun, Yu-Lin; Bao, Jie; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
项目归属: LMB
摘要: Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus Penicillium oxalicum SCSGAF 0023, Meripilaceae family. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 was established by using the modified Mosher ester method and circular dichroism data of in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complexes. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 is discussed.
语种: 英语
WOS记录号: WOS:000312554100011
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9738
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Sun, YL; He, F; Liu, KS; Zhang, XY; Bao, J; Wang, YF; Nong, XH; Xu, XY; Qi, SH.Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum,PLANTA MEDICA,2012,78(18):1957-1961
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