Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum
Sun, YL; He, F; Liu, KS; Zhang, XY; Bao, J; Wang, YF; Nong, XH; Xu, XY; Qi, SH; shuhuaqi@scsio.ac.cn
2012
发表期刊PLANTA MEDICA
ISSN0032-0943
卷号78期号:18页码:1957-1961
摘要Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus Penicillium oxalicum SCSGAF 0023, Meripilaceae family. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 was established by using the modified Mosher ester method and circular dichroism data of in situ formed [Rh-2(OCOCF3)(4)] and [Mo-2(OAc)(4)] complexes. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 mu M, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 mu M, respectively. The structure-biological activity relationship of 1 is discussed.
部门归属[Sun, Yu-Lin; He, Fei; Zhang, Xiao-Yong; Bao, Jie; Nong, Xu-Hua; Xu, Xin-Ya; Qi, Shu-Hua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Kai-Sheng; Wang, Yi-Fei] Jinan Univ, Guangzhou, Guangdong, Peoples R China; [Sun, Yu-Lin; Bao, Jie; Nong, Xu-Hua] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
关键词Penicillium Oxalicum Scsgaf 0023 Meripilaceae Family Dihydrothiophene-condensed Chromone Cytotoxicity
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种英语
资助项目LMB
WOS记录号WOS:000312554100011
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9738
专题中科院海洋生物资源可持续利用重点实验室
通讯作者shuhuaqi@scsio.ac.cn
推荐引用方式
GB/T 7714
Sun, YL,He, F,Liu, KS,et al. Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum[J]. PLANTA MEDICA,2012,78(18):1957-1961.
APA Sun, YL.,He, F.,Liu, KS.,Zhang, XY.,Bao, J.,...&shuhuaqi@scsio.ac.cn.(2012).Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum.PLANTA MEDICA,78(18),1957-1961.
MLA Sun, YL,et al."Cytotoxic Dihydrothiophene-Condensed Chromones from Marine-Derived Fungus Penicillium oxalicum".PLANTA MEDICA 78.18(2012):1957-1961.
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