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学科主题: Chemistry, Medicinal; Chemistry, Organic
题名: Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
作者: Wang, FZ ; Huang, Z ; Shi, XF ; Chen, YC ; Zhang, WM ; Tian, XP ; Li, J ; Zhang, S
通讯作者: zhsimd@scsio.ac.cn
关键词: Indole diketopiperazine ; Cytotoxicity ; Acrostalagmus luteoalbus ; Marine fungi ; Deep-sea sediment
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2012
卷: 22, 期:23, 页:7265-7267
部门归属: [Wang, Fa-Zuo; Huang, Zhi; Shi, Xue-Feng; Tian, Xin-Peng; Li, Jie; Zhang, Si] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Yu-Chan; Zhang, Wei-Min] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
项目归属: LMB
摘要: Two new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. (C) 2012 Published by Elsevier Ltd.
语种: 英语
WOS记录号: WOS:000310583100056
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9742
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Wang, FZ; Huang, Z; Shi, XF; Chen, YC; Zhang, WM; Tian, XP; Li, J; Zhang, S.Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(23):7265-7267
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