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Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
Wang, FZ; Huang, Z; Shi, XF; Chen, YC; Zhang, WM; Tian, XP; Li, J; Zhang, S; zhsimd@scsio.ac.cn
2012
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume22Issue:23Pages:7265-7267
AbstractTwo new indole diketopiperazines, namely luteoalbusins A-B (1-2), along with eight known ones (3-10), were isolated from the fungus Acrostalagmus luteoalbus SCSIO F457 originated from deep-sea sediment. Their structures were determined by 1D/2D NMR, MS, and CD data analyses. Each of these compounds was evaluated for their cytotoxic activities against SF-268, MCF-7, NCI-H460, and HepG-2 cell lines, and compounds 1-5 showed significant cytotoxicties against all four cancer cell lines. Moreover, new compounds 1 and 2 had more potent cytotoxicity than the other ones and cisplatin. (C) 2012 Published by Elsevier Ltd.
Department[Wang, Fa-Zuo; Huang, Zhi; Shi, Xue-Feng; Tian, Xin-Peng; Li, Jie; Zhang, Si] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Yu-Chan; Zhang, Wei-Min] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
KeywordIndole Diketopiperazine Cytotoxicity Acrostalagmus Luteoalbus Marine Fungi Deep-sea Sediment
Subject AreaChemistry, Medicinal ; Chemistry, Organic
Language英语
Funding ProjectLMB
WOS IDWOS:000310583100056
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/9742
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorzhsimd@scsio.ac.cn
Recommended Citation
GB/T 7714
Wang, FZ,Huang, Z,Shi, XF,et al. Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(23):7265-7267.
APA Wang, FZ.,Huang, Z.,Shi, XF.,Chen, YC.,Zhang, WM.,...&zhsimd@scsio.ac.cn.(2012).Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(23),7265-7267.
MLA Wang, FZ,et al."Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.23(2012):7265-7267.
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