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学科主题: Chemistry, Organic
题名: Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis
作者: Li, B ; Kong, DY ; Shen, YH ; Yuan, H ; Yue, RC ; He, YR ; Lu, L ; Shan, L ; Li, HL ; Ye, J ; Yang, XW ; Su, J ; Liu, RH ; Zhang, WD
通讯作者: shenyunheng9217018@yahoo.com.cn ; wdzhangy@hotmail.com
刊名: ORGANIC LETTERS
发表日期: 2012
卷: 14, 期:21, 页:5432-5435
部门归属: [Li, Bo; Shen, Yun-Heng; Yuan, Hu; Yue, Rong-Cai; He, Yi-Ren; Lu, Lu; Shan, Lei; Li, Hui-Liang; Ye, Ji; Yang, Xian-Wen; Su, Juan; Liu, Run-Hui; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China; [Li, Bo; Kong, De-Yun] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 200040, Peoples R China; [Zhang, Wei-Dong] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Pseudolaridimers A (1) and B (2), two unprecedented heterodimers formed via a [4 + 2] Diels - Alder cycloaddition between a cycloartane triterpenoid unit and a labdane diterpenoid unit, were isolated from the cones of Pseudolarix amabilis. Their structures were established by extensive analysis of HRESIMS and NMR spectra. The absolute configuration of 1 was determined by single crystal X-ray diffraction (Cu K-alpha) of its methyl esterified derivative. Pseudolaridimer A (1) showed strong cytotoxicity against HCT116, ZR-75-30, and HL-60 human tumor cell lines, with IC50 values 9.62, 7.84, 8.29 mu g/mL, respectively. Pseudolaridimer B (2) only exhibited potent inhibition against the HL-60 cell line with an IC50 value of 7.50 mu g/mL.
语种: 英语
WOS记录号: WOS:000311245600013
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9746
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, B; Kong, DY; Shen, YH; Yuan, H; Yue, RC; He, YR; Lu, L; Shan, L; Li, HL; Ye, J; Yang, XW; Su, J; Liu, RH; Zhang, WD.Pseudolaridimers A and B, Hetero-Cycloartane-Labdane Diels-Alder Adducts from the Cone of Pseudolarix amabilis,ORGANIC LETTERS,2012,14(21):5432-5435
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