Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160
Zhang, WJ; Liu, Z; Li, SM; Lu, YZ; Chen, YC; Zhang, HB; Zhang, GT; Zhu, YG; Zhang, GY; Zhang, WM; Liu, JS; Zhang, CS; czhang2006@gmail.com
2012
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:11页码:1937-1943
摘要The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 mu g/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 mu M) and MCF-7 (IC50 0.17 mu M).
部门归属[Zhang, Wenjun; Li, Sumei; Zhang, Haibo; Zhang, Guangtao; Zhu, Yiguang; Zhang, Gaiyun; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangdong Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China; [Lu, Yongzhi; Liu, Jinsong] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
语种英语
资助项目LMB
WOS记录号WOS:000311461300010
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9756
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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GB/T 7714
Zhang, WJ,Liu, Z,Li, SM,et al. Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1937-1943.
APA Zhang, WJ.,Liu, Z.,Li, SM.,Lu, YZ.,Chen, YC.,...&czhang2006@gmail.com.(2012).Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160.JOURNAL OF NATURAL PRODUCTS,75(11),1937-1943.
MLA Zhang, WJ,et al."Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1937-1943.
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