中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160
作者: Zhang, WJ ; Liu, Z ; Li, SM ; Lu, YZ ; Chen, YC ; Zhang, HB ; Zhang, GT ; Zhu, YG ; Zhang, GY ; Zhang, WM ; Liu, JS ; Zhang, CS
通讯作者: czhang2006@gmail.com
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2012
卷: 75, 期:11, 页:1937-1943
部门归属: [Zhang, Wenjun; Li, Sumei; Zhang, Haibo; Zhang, Guangtao; Zhu, Yiguang; Zhang, Gaiyun; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangdong Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China; [Lu, Yongzhi; Liu, Jinsong] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
项目归属: LMB
摘要: The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 mu g/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 mu M) and MCF-7 (IC50 0.17 mu M).
语种: 英语
WOS记录号: WOS:000311461300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9756
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Fluostatins I-K from the South China Sea-Derived.pdf(958KB)----开放获取--View Download

Recommended Citation:
Zhang, WJ; Liu, Z; Li, SM; Lu, YZ; Chen, YC; Zhang, HB; Zhang, GT; Zhu, YG; Zhang, GY; Zhang, WM; Liu, JS; Zhang, CS.Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160,JOURNAL OF NATURAL PRODUCTS,2012,75(11):1937-1943
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, WJ]'s Articles
[Liu, Z]'s Articles
[Li, SM]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, WJ]‘s Articles
[Liu, Z]‘s Articles
[Li, SM]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Fluostatins I-K from the South China Sea-Derived.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace