Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice
Xiao, C; Wu, QP; Cai, W; Tan, JB; Yang, XB; Zhang, JM; xiaochun960@hotmail.com; 13823320821@139.com
2012
发表期刊ARCHIVES OF PHARMACAL RESEARCH
ISSN0253-6269
卷号35期号:10页码:1793-1801
摘要Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. The mice were randomly divided into four groups (8 mice/group): normal control group, diabetic control group, low-dose GLP-treated diabetic group (50 mg/kg/d), and high-dose GLP-treated diabetic group (100 mg/kg/d). Diabetes was induced by streptozotocin injection and high-fat dietary feeding. At the end of the study, fasting serum glucose, insulin, body weight (BW) and epididymal white adipose tissue weight were measured. The hepatic mRNA levels of glycogen phosphorylase (GP), fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) genes were determined by real-time polymerase chain reaction. Both doses of GLPs significantly decreased fasting serum glucose, insulin and epididymal fat/BW ratio compared with the diabetic control group (p < 0.05). The hepatic mRNA levels of GP, FBPase, PEPCK and G6Pase were significantly lower in both GLP-treated groups compared with the diabetic control group. Taken together, GLPs significantly decrease fasting serum glucose levels in type 2 diabetic mice in a dose-dependent manner. The decreases in fasting serum glucose levels may be associated with decreased mRNA expression levels of several key enzymes involved in gluconeogenesis and/or glycogenolysis.
部门归属[Xiao, Chun; Wu, Qing-Ping; Yang, Xiao-Bing; Zhang, Ju-Mei] Guangdong Inst Microbiol, State Key Lab Appl Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol,Minist Guangdon, Guangzhou 510070, Guangdong, Peoples R China; [Xiao, Chun] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Xiao, Chun] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Cai, Wen; Tan, Jian-Bin] Ctr Dis Control & Prevent Guangdong Prov, Dept Toxicol, Guangzhou 510020, Peoples R China
关键词Ganoderma Lucidum Polysaccharides Hypoglycemic Activity Type 2 Diabetes Mellitus
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
语种英语
资助项目LMB
WOS记录号WOS:000310950500013
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9778
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xiaochun960@hotmail.com; 13823320821@139.com
推荐引用方式
GB/T 7714
Xiao, C,Wu, QP,Cai, W,et al. Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(10):1793-1801.
APA Xiao, C.,Wu, QP.,Cai, W.,Tan, JB.,Yang, XB.,...&13823320821@139.com.(2012).Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice.ARCHIVES OF PHARMACAL RESEARCH,35(10),1793-1801.
MLA Xiao, C,et al."Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice".ARCHIVES OF PHARMACAL RESEARCH 35.10(2012):1793-1801.
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