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学科主题: Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice
作者: Xiao, C ; Wu, QP ; Cai, W ; Tan, JB ; Yang, XB ; Zhang, JM
通讯作者: xiaochun960@hotmail.com ; 13823320821@139.com
关键词: Ganoderma lucidum polysaccharides ; Hypoglycemic activity ; Type 2 diabetes mellitus
刊名: ARCHIVES OF PHARMACAL RESEARCH
发表日期: 2012
卷: 35, 期:10, 页:1793-1801
部门归属: [Xiao, Chun; Wu, Qing-Ping; Yang, Xiao-Bing; Zhang, Ju-Mei] Guangdong Inst Microbiol, State Key Lab Appl Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol,Minist Guangdon, Guangzhou 510070, Guangdong, Peoples R China; [Xiao, Chun] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China; [Xiao, Chun] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Cai, Wen; Tan, Jian-Bin] Ctr Dis Control & Prevent Guangdong Prov, Dept Toxicol, Guangzhou 510020, Peoples R China
项目归属: LMB
摘要: Our aims were to investigate the hypoglycemic effects and mechanisms of action of Ganoderma lucidum polysaccharides (GLPs) administered for 7 days in type 2 diabetic mice. The mice were randomly divided into four groups (8 mice/group): normal control group, diabetic control group, low-dose GLP-treated diabetic group (50 mg/kg/d), and high-dose GLP-treated diabetic group (100 mg/kg/d). Diabetes was induced by streptozotocin injection and high-fat dietary feeding. At the end of the study, fasting serum glucose, insulin, body weight (BW) and epididymal white adipose tissue weight were measured. The hepatic mRNA levels of glycogen phosphorylase (GP), fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) genes were determined by real-time polymerase chain reaction. Both doses of GLPs significantly decreased fasting serum glucose, insulin and epididymal fat/BW ratio compared with the diabetic control group (p < 0.05). The hepatic mRNA levels of GP, FBPase, PEPCK and G6Pase were significantly lower in both GLP-treated groups compared with the diabetic control group. Taken together, GLPs significantly decrease fasting serum glucose levels in type 2 diabetic mice in a dose-dependent manner. The decreases in fasting serum glucose levels may be associated with decreased mRNA expression levels of several key enzymes involved in gluconeogenesis and/or glycogenolysis.
语种: 英语
WOS记录号: WOS:000310950500013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9778
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Xiao, C; Wu, QP; Cai, W; Tan, JB; Yang, XB; Zhang, JM.Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice,ARCHIVES OF PHARMACAL RESEARCH,2012,35(10):1793-1801
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