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学科主题: Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
题名: Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas
作者: Yu, F ; Zhang, Y ; Yu, ZN
通讯作者: carlzyu@scsio.ac.cn
关键词: Crassostrea gigas ; LITAF ; Expression pattern ; Immune response ; Diversification
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2012
卷: 33, 期:4, 页:899-908
部门归属: [Yu, Feng; Zhang, Yang; Yu, Ziniu] Chinese Acad Sci, S China Sea Inst Oceanol, Lab Appl Marine Biol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Yu, Feng] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
项目归属: LMB
摘要: Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) is a novel transcription factor responsible for lipopolysaccharide (LPS)-induced transcription of tumor necrosis factor-alpha. Here, we identified and characterized five new LITAF genes in a mollusk, Crassostrea gigas. The complete cDNA sequences of these newly-cloned CgLITAFs each contain one small ORF encoding putative proteins ranging from 67 to 132 amino acids in length. Each CgLITAF, except LITAF2, includes a conserved domain with two motifs, (H)XCXXC and CXXC; LITAF2 lacks the N-terminal CXXC motif. Phylogenetic analysis shows that the six CgLITAFs members (including a previously reported one) cluster into two different mollusk LITAF branches, implying an ancient origin of two LITAF genes that later diversified. CgLITAF members show distinct gene expression patterns with higher expression in digestive gland, gill, and mantle. Except for LITAF4 and LITAF6. CgLITAF expressions can be induced selectively and to various degrees by different Pathogen-Associated Molecular Patterns (PAMPs). Our results strongly demonstrated that the CgLITAF gene family has diversified in function such that each gene plays a distinct and non-redundant role in host defense of C. gigas. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000310185800026
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9782
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Yu, F; Zhang, Y; Yu, ZN.Characteristics and expression patterns of the lipopolysaccharide-induced TNF-alpha factor (LITAF) gene family in the Pacific oyster, Crassostrea gigas,FISH & SHELLFISH IMMUNOLOGY,2012,33(4):899-908
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