N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete
Zhang, QB; Mandi, A; Li, SM; Chen, YC; Zhang, WJ; Tian, XP; Zhang, HB; Li, HX; Zhang, WM; Zhang, S; Ju, JH; Kurtan, T; Zhang, CS; kurtan.tibor@science.unideb.hu; czhang2006@gmail.com
2012
发表期刊EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN1434-193X
期号27页码:5256-5262
摘要Four new indolo-sesquiterpenes dixiamycins A (1) and B (2), oxiamycin (3), and chloroxiamycin (4) were isolated from a marine-derived Actinomycete and characterized, together with the known compound xiamycin A (5). Dixiamycins A (1) and B (2) are the first examples of atropisomerism of naturally occurring N-N-coupled atropo-diastereomers, with a dimeric indolo-sesquiterpene skeleton and a stereogenic N-N axis between sp3-hybridized nitrogen atoms. Solution TDDFT ECD calculations were utilized to ascertain the axial chirality of 1 and 2, and rotational barriers and transitions states of the inversion were calculated. Oxiamycin (3) contains a seven-membered 2,3,4,5-tetrahydrooxepine ring. The two dimeric compounds 1 and 2 showed better antibacterial activities than the monomers 35.
部门归属[Mandi, Attila; Kurtan, Tibor] Debrecen Univ Med, Dept Organ Chem, H-4010 Debrecen, Hungary; [Zhang, Qingbo; Li, Sumei; Zhang, Wenjun; Tian, Xinpeng; Zhang, Haibo; Li, Huixian; Zhang, Si; Ju, Jianhua; Zhang, Changsheng] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,S China Sea Inst, Guangzhou 510301, Guangdong, Peoples R China; [Zhang, Qingbo] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Chen, Yuchan; Zhang, Weimin] Guangdong Inst Microbiol, Guangzhou 510070, Guangdong, Peoples R China
关键词Natural Products Terpenoids Xiamycin Atropisomerism Configuration Determination Density Functional Calculations
学科领域Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000308580800016
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9818
专题中科院海洋生物资源可持续利用重点实验室
通讯作者kurtan.tibor@science.unideb.hu; czhang2006@gmail.com
推荐引用方式
GB/T 7714
Zhang, QB,Mandi, A,Li, SM,et al. N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(27):5256-5262.
APA Zhang, QB.,Mandi, A.,Li, SM.,Chen, YC.,Zhang, WJ.,...&czhang2006@gmail.com.(2012).N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(27),5256-5262.
MLA Zhang, QB,et al."N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .27(2012):5256-5262.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
N-N-Coupled Indolo-s(631KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。