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学科主题: Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
题名: Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata
作者: Huang, XD ; Liu, WG ; Guan, YY ; Shi, Y ; Wang, Q ; Zhao, M ; Wu, SZ ; He, MX
通讯作者: hmx@scsio.ac.cn
关键词: Pearl oyster ; PfTRAF3 ; Immune response ; Vibrio alginolyticus
刊名: FISH & SHELLFISH IMMUNOLOGY
发表日期: 2012
卷: 33, 期:3, 页:652-658
部门归属: [Huang, Xian-De; Liu, Wen-Guang; Guan, Yun-Yan; Shi, Yu; Wang, Qi; Zhao, Mi; Wu, Shan-Zeng; He, Mao-Xian] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: TRAF3 is a highly versatile regulator that negatively regulates JNK and alternative nuclear factor-kappa B signalling, but positively controls type I interferon production. To investigate TRAF3 function in innate immune responses among invertebrate especially mollusk, we characterized TRAF3 (PfTRAF3) from pearl oyster Pinctada fucata, one of the most important bivalve mollusks for seawater pearl production. PfTRAF3 cDNA is 2261 bp with an open reading frame of 1623 bp encoding a putative protein of 541 amino acids. The deduced PfTRAF3 contains a RING finger domain, two TRAF domains with zinc finger domains and a conserved C-terminal meprin and TRAF homology (MATH) domain. Comparison and phylogenetic analysis revealed that PfTRAF3 from mollusk shared a higher identity with Ciona intestinalis TRAF3 from urochordata, Branchiostoma belcheri TRAF3 from cephalochordate, and even TRAF3 from vertebrate than with insect homologues. Furthermore, gene expression analyses suggested that PfTRAF3 was involved in the immune response to Vibrio alginolyticus. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000308057700024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9820
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Huang, XD; Liu, WG; Guan, YY; Shi, Y; Wang, Q; Zhao, M; Wu, SZ; He, MX.Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata,FISH & SHELLFISH IMMUNOLOGY,2012,33(3):652-658
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