Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata
Huang, XD; Liu, WG; Guan, YY; Shi, Y; Wang, Q; Zhao, M; Wu, SZ; He, MX; hmx@scsio.ac.cn
2012
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号33期号:3页码:652-658
摘要TRAF3 is a highly versatile regulator that negatively regulates JNK and alternative nuclear factor-kappa B signalling, but positively controls type I interferon production. To investigate TRAF3 function in innate immune responses among invertebrate especially mollusk, we characterized TRAF3 (PfTRAF3) from pearl oyster Pinctada fucata, one of the most important bivalve mollusks for seawater pearl production. PfTRAF3 cDNA is 2261 bp with an open reading frame of 1623 bp encoding a putative protein of 541 amino acids. The deduced PfTRAF3 contains a RING finger domain, two TRAF domains with zinc finger domains and a conserved C-terminal meprin and TRAF homology (MATH) domain. Comparison and phylogenetic analysis revealed that PfTRAF3 from mollusk shared a higher identity with Ciona intestinalis TRAF3 from urochordata, Branchiostoma belcheri TRAF3 from cephalochordate, and even TRAF3 from vertebrate than with insect homologues. Furthermore, gene expression analyses suggested that PfTRAF3 was involved in the immune response to Vibrio alginolyticus. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Huang, Xian-De; Liu, Wen-Guang; Guan, Yun-Yan; Shi, Yu; Wang, Qi; Zhao, Mi; Wu, Shan-Zeng; He, Mao-Xian] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Pearl Oyster Pftraf3 Immune Response Vibrio Alginolyticus
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
资助项目LMB
WOS记录号WOS:000308057700024
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9820
专题中科院海洋生物资源可持续利用重点实验室
通讯作者hmx@scsio.ac.cn
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Huang, XD,Liu, WG,Guan, YY,et al. Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata[J]. FISH & SHELLFISH IMMUNOLOGY,2012,33(3):652-658.
APA Huang, XD.,Liu, WG.,Guan, YY.,Shi, Y.,Wang, Q.,...&hmx@scsio.ac.cn.(2012).Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata.FISH & SHELLFISH IMMUNOLOGY,33(3),652-658.
MLA Huang, XD,et al."Molecular cloning, characterization and expression analysis of tumor necrosis factor receptor-associated factor 3 (TRAF3) from pearl oyster Pinctada fucata".FISH & SHELLFISH IMMUNOLOGY 33.3(2012):652-658.
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