Molecular cloning and characterization of class I NF-kappa B transcription factor from pearl oyster (Pinctada fucata)
Huang, XD; Liu, WG; Guan, YY; Shi, Y; Wang, Q; Zhao, M; Wu, SZ; He, MX; hmx@scsio.ac.cn
2012
发表期刊FISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
卷号33期号:3页码:659-666
摘要NF-kappa B transcription factors play central roles in many important physiological and pathological processes including innate immune responses. Here we report the cloning of an NF-kappa B transcription factor. PfRelish from pearl oyster Pinctada fucata, one of the most important bivalve mollusks for seawater pearl production. PfRelish full-length cDNA is 3916 bp with an open reading frame of 3558 bp encoding a putative protein of 1186 amino acids. The deduced PfRelish contains a N-terminal RHD, a nucleus localization signal, an I kappa B-like domain with six ankyrin repeats and a death domain at the C-terminus, which is similar to class I NF-kappa B transcription factors. Comparison and phylogenetic analysis revealed that class I NF-kappa Bs in mollusks including PfRelish might have most distant relationship to the arthropod Relish. Further expression analysis showed that PfRelish was apparently upregulated after Vibrio alginolyticus injection, which suggested that PfRelish was involved in the immune response to V. alginolyticus. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Huang, Xian-De; Liu, Wen-Guang; Guan, Yun-Yan; Shi, Yu; Wang, Qi; Zhao, Mi; Wu, Shan-Zeng; He, Mao-Xian] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Pearl Oyster Class i Nif Kappa b Transcription Factor Gene Cloning Immunity Response
学科领域Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
资助项目LMB
WOS记录号WOS:000308057700025
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被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9822
专题中科院海洋生物资源可持续利用重点实验室
通讯作者hmx@scsio.ac.cn
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Huang, XD,Liu, WG,Guan, YY,et al. Molecular cloning and characterization of class I NF-kappa B transcription factor from pearl oyster (Pinctada fucata)[J]. FISH & SHELLFISH IMMUNOLOGY,2012,33(3):659-666.
APA Huang, XD.,Liu, WG.,Guan, YY.,Shi, Y.,Wang, Q.,...&hmx@scsio.ac.cn.(2012).Molecular cloning and characterization of class I NF-kappa B transcription factor from pearl oyster (Pinctada fucata).FISH & SHELLFISH IMMUNOLOGY,33(3),659-666.
MLA Huang, XD,et al."Molecular cloning and characterization of class I NF-kappa B transcription factor from pearl oyster (Pinctada fucata)".FISH & SHELLFISH IMMUNOLOGY 33.3(2012):659-666.
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