Cytotoxic triterpenoids from Abies recurvata
Li, YL; Gao, YX; Yang, XW; Jin, HZ; Ye, J; Simmons, L; Wang, N; Steinmetz, A; Zhang, WD; xianwen.yang@crp-sante.lu; wdzhangy@hot-mail.com
2012
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号81页码:159-164
摘要Nine triterpenoids (neoabiestrines A-1, 1-9) including six rearranged lanostanes (1-6) and a rare cyclo-art-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC50 value of 17.8 mu g/mL. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Yang, Xian-Wen; Simmons, Luke; Wang, Ning; Steinmetz, Andre] Luxembourg Publ Res Ctr Hlth CRP SANTE, Dept Oncol, Cellular & Mol Oncol Lab, L-1526 Luxembourg, Luxembourg; [Li, Yong-Li; Jin, Hui-Zi; Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China; [Gao, Yan-Xia; Ye, Ji; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Abies Recurvata Pinaceae Triterpenoids Cu-ka X-ray Crystallography Cytotoxicity
学科领域Biochemistry & Molecular Biology ; Plant Sciences
语种英语
资助项目LMB
WOS记录号WOS:000308121000018
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9832
专题中科院海洋生物资源可持续利用重点实验室
通讯作者xianwen.yang@crp-sante.lu; wdzhangy@hot-mail.com
推荐引用方式
GB/T 7714
Li, YL,Gao, YX,Yang, XW,et al. Cytotoxic triterpenoids from Abies recurvata[J]. PHYTOCHEMISTRY,2012,81:159-164.
APA Li, YL.,Gao, YX.,Yang, XW.,Jin, HZ.,Ye, J.,...&wdzhangy@hot-mail.com.(2012).Cytotoxic triterpenoids from Abies recurvata.PHYTOCHEMISTRY,81,159-164.
MLA Li, YL,et al."Cytotoxic triterpenoids from Abies recurvata".PHYTOCHEMISTRY 81(2012):159-164.
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