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学科主题: Biochemistry & Molecular Biology; Plant Sciences
题名: Cytotoxic triterpenoids from Abies recurvata
作者: Li, YL ; Gao, YX ; Yang, XW ; Jin, HZ ; Ye, J ; Simmons, L ; Wang, N ; Steinmetz, A ; Zhang, WD
通讯作者: xianwen.yang@crp-sante.lu ; wdzhangy@hot-mail.com
关键词: Abies recurvata ; Pinaceae ; Triterpenoids ; Cu-Ka X-ray crystallography ; Cytotoxicity
刊名: PHYTOCHEMISTRY
发表日期: 2012
卷: 81, 页:159-164
部门归属: [Yang, Xian-Wen; Simmons, Luke; Wang, Ning; Steinmetz, Andre] Luxembourg Publ Res Ctr Hlth CRP SANTE, Dept Oncol, Cellular & Mol Oncol Lab, L-1526 Luxembourg, Luxembourg; [Li, Yong-Li; Jin, Hui-Zi; Zhang, Wei-Dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China; [Gao, Yan-Xia; Ye, Ji; Zhang, Wei-Dong] Mil Med Coll 2, Sch Pharm, Dept Nat Prod Chem, Shanghai 200433, Peoples R China; [Yang, Xian-Wen] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Nine triterpenoids (neoabiestrines A-1, 1-9) including six rearranged lanostanes (1-6) and a rare cyclo-art-7-ene (7) were isolated from Abies recurvata together with ten known compounds. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The absolute configurations of 1 and 8 were determined by Cu-Ka X-ray crystallography. Compound 6 showed potent anti-proliferative effect against THP-1 tumor cells with an IC50 value of 17.8 mu g/mL. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000308121000018
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内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9832
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Li, YL; Gao, YX; Yang, XW; Jin, HZ; Ye, J; Simmons, L; Wang, N; Steinmetz, A; Zhang, WD.Cytotoxic triterpenoids from Abies recurvata,PHYTOCHEMISTRY,2012,81():159-164
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