Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete
Zhang, WJ; Liu, Z; Li, SM; Yang, TT; Zhang, QB; Ma, L; Tian, XP; Zhang, HB; Huang, CG; Zhang, S; Ju, JH; Shen, YM; Zhang, CS; czhang2006@gmail.com
2012
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号14期号:13页码:3364-3367
摘要A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiroring containing skeletons. Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.
部门归属[Zhang, Wenjun; Li, Sumei; Zhang, Qingbo; Ma, Liang; Tian, Xinpeng; Zhang, Haibo; Zhang, Si; Ju, Jianhua; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangdong Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China; [Yang, Tingting; Huang, Caiguo] Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China; [Shen, Yuemao] Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
学科领域Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000306050300033
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9858
专题中科院海洋生物资源可持续利用重点实验室
通讯作者czhang2006@gmail.com
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GB/T 7714
Zhang, WJ,Liu, Z,Li, SM,et al. Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete[J]. ORGANIC LETTERS,2012,14(13):3364-3367.
APA Zhang, WJ.,Liu, Z.,Li, SM.,Yang, TT.,Zhang, QB.,...&czhang2006@gmail.com.(2012).Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete.ORGANIC LETTERS,14(13),3364-3367.
MLA Zhang, WJ,et al."Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete".ORGANIC LETTERS 14.13(2012):3364-3367.
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