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学科主题: Chemistry, Organic
题名: Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete
作者: Zhang, WJ ; Liu, Z ; Li, SM ; Yang, TT ; Zhang, QB ; Ma, L ; Tian, XP ; Zhang, HB ; Huang, CG ; Zhang, S ; Ju, JH ; Shen, YM ; Zhang, CS
通讯作者: czhang2006@gmail.com
刊名: ORGANIC LETTERS
发表日期: 2012
卷: 14, 期:13, 页:3364-3367
部门归属: [Zhang, Wenjun; Li, Sumei; Zhang, Qingbo; Ma, Liang; Tian, Xinpeng; Zhang, Haibo; Zhang, Si; Ju, Jianhua; Zhang, Changsheng] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Liu, Zhong] Jinan Univ, Guangzhoujinan Biomed Res & Dev Ctr, Guangdong Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China; [Yang, Tingting; Huang, Caiguo] Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China; [Shen, Yuemao] Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
项目归属: LMB
摘要: A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiroring containing skeletons. Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.
语种: 英语
WOS记录号: WOS:000306050300033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9858
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Zhang, WJ; Liu, Z; Li, SM; Yang, TT; Zhang, QB; Ma, L; Tian, XP; Zhang, HB; Huang, CG; Zhang, S; Ju, JH; Shen, YM; Zhang, CS.Spiroindimicins A-D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete,ORGANIC LETTERS,2012,14(13):3364-3367
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