Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity
Luo, XM; He, WH; Yin, H; Li, QX; Liu, Q; Huang, YZ; Zhang, S; luoxm163@sina.com; whhe@scsio.ac.cn; yinhao@scsio.ac.cn; liqx81@163.com; lq_11@hotmail.com; tj6188@sina.com; zhsimd@scsio.ac.cn
2012
发表期刊MOLECULES
ISSN1420-3049
卷号17期号:6页码:6944-6952
摘要Two new coumarins, 7-methoxy-8-(2-hydroxmethyl-1-O-isovaleryl-4-butenyl)coumarin (1) and 7-methoxy-8-(1-hydroxy-2-O-beta-glucopyranosyl-3-methyl-4-butene-1-yl) coumarin (2), and twelve known coumarins 3-14 were isolated from the stem bark of Micromelum falcatum. The structures of compounds 1-14 were elucidated by extensive spectroscopic data analyses. The toxicity of compounds 1-14 was tested using a brine shrimp assay and in vitro antiproliferative assay against mammary cancer (F10) and lung cancer (HvEvc) cell lines by the MTT method. Some compounds had moderate activities. All compounds were also tested against the microorganisms Bacillus subtilis, Bacillus thuringiensis and Escherichia coli, but no activity was observed.
部门归属[Luo, Xiongming; He, Weihong; Yin, Hao; Li, Qingxin; Liu, Qiao; Huang, Yongzhong; Zhang, Si] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresourses Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
关键词Micromelum Falcatum Coumarins Brine Shrimp Larvae Toxicity Cytotoxicity Antibacterial Activity
学科领域Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000305800400052
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文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9884
专题中科院海洋生物资源可持续利用重点实验室
通讯作者luoxm163@sina.com; whhe@scsio.ac.cn; yinhao@scsio.ac.cn; liqx81@163.com; lq_11@hotmail.com; tj6188@sina.com; zhsimd@scsio.ac.cn
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Luo, XM,He, WH,Yin, H,et al. Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity[J]. MOLECULES,2012,17(6):6944-6952.
APA Luo, XM.,He, WH.,Yin, H.,Li, QX.,Liu, Q.,...&zhsimd@scsio.ac.cn.(2012).Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity.MOLECULES,17(6),6944-6952.
MLA Luo, XM,et al."Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity".MOLECULES 17.6(2012):6944-6952.
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