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学科主题: Chemistry, Organic
题名: Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity
作者: Luo, XM ; He, WH ; Yin, H ; Li, QX ; Liu, Q ; Huang, YZ ; Zhang, S
通讯作者: luoxm163@sina.com ; whhe@scsio.ac.cn ; yinhao@scsio.ac.cn ; liqx81@163.com ; lq_11@hotmail.com ; tj6188@sina.com ; zhsimd@scsio.ac.cn
关键词: Micromelum falcatum ; coumarins ; brine shrimp larvae toxicity ; cytotoxicity ; antibacterial activity
刊名: MOLECULES
发表日期: 2012
卷: 17, 期:6, 页:6944-6952
部门归属: [Luo, Xiongming; He, Weihong; Yin, Hao; Li, Qingxin; Liu, Qiao; Huang, Yongzhong; Zhang, Si] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresourses Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Two new coumarins, 7-methoxy-8-(2-hydroxmethyl-1-O-isovaleryl-4-butenyl)coumarin (1) and 7-methoxy-8-(1-hydroxy-2-O-beta-glucopyranosyl-3-methyl-4-butene-1-yl) coumarin (2), and twelve known coumarins 3-14 were isolated from the stem bark of Micromelum falcatum. The structures of compounds 1-14 were elucidated by extensive spectroscopic data analyses. The toxicity of compounds 1-14 was tested using a brine shrimp assay and in vitro antiproliferative assay against mammary cancer (F10) and lung cancer (HvEvc) cell lines by the MTT method. Some compounds had moderate activities. All compounds were also tested against the microorganisms Bacillus subtilis, Bacillus thuringiensis and Escherichia coli, but no activity was observed.
语种: 英语
WOS记录号: WOS:000305800400052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9884
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Luo, XM; He, WH; Yin, H; Li, QX; Liu, Q; Huang, YZ; Zhang, S.Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity,MOLECULES,2012,17(6):6944-6952
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文件名: Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity.pdf
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