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学科主题: Chemistry, Organic
题名: Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase
作者: Zhu, YG ; Fu, P ; Lin, QH ; Zhang, GT ; Zhang, HB ; Li, SM ; Ju, JH ; Zhu, WM ; Zhang, CS
通讯作者: weimingzhu@ouc.edu.cn ; czhang2006@gmail.com
刊名: ORGANIC LETTERS
发表日期: 2012
卷: 14, 期:11, 页:2666-2669
部门归属: [Fu, Peng; Zhu, Weiming] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China; [Zhu, Yiguang; Lin, Qinheng; Zhang, Guangtao; Zhang, Haibo; Li, Sumei; Ju, Jianhua; Zhang, Changsheng] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, CAS Key Lab Marine Bioresources Sustainable Utili, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: The biosynthetic gene cluster for caerulomycin A (1) was cloned and characterized from the marine actinomycete Actinoalloteichus cyanogriseus WH1-2216-6, which revealed an unusual hybrid polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) system. The crmL disruption mutant accumulated caerulomycin L (2) with an extended L-leucine at C-7, implicating an amidohydrolase activity for CrmL. The leucine-removing activity was confirmed for crude CrmL enzymes. Heterologous expression of the 1 gene cluster led to 1 production in Streptomyces coelicolor.
语种: 英语
WOS记录号: WOS:000304682700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9888
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Zhu, YG; Fu, P; Lin, QH; Zhang, GT; Zhang, HB; Li, SM; Ju, JH; Zhu, WM; Zhang, CS.Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase,ORGANIC LETTERS,2012,14(11):2666-2669
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文件名: Identification of Caerulomycin A Gene Cluster Implicates a Tailoring Amidohydrolase.pdf
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