中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Chemistry, Medicinal; Chemistry, Organic
题名: Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
作者: La Kim, E ; Li, JL ; Dang, HT ; Hong, J ; Lee, CO ; Kim, DK ; Yoon, WD ; Kim, E ; Liu, YH ; Jung, JH
通讯作者: jhjung@pusan.ac.kr
关键词: Cytochalasin ; Jellyfish-derived fungus ; Phoma sp. ; Nemopilema nomurai ; Cytotoxicity
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2012
卷: 22, 期:9, 页:3126-3129
部门归属: [La Kim, Eun; Li, Jian Lin; Dang, Hung The; Jung, Jee H.] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea; [Hong, Jongki] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea; [Lee, Chong-Ok] Korea Res Inst Chem Technol, Taejon 305343, South Korea; [Kim, Dong-Kyoo] Inje Univ, Dept Chem, Gimhae 621749, South Korea; [Yoon, Won Duk] Natl Fisheries Res & Dev Inst, Pusan 619705, South Korea; [Kim, Euikyung] Gyeongsang Natl Univ, Coll Vet Med, Jinju 660701, South Korea; [Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000302964300017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9924
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai.pdf(416KB)----开放获取--View Download

Recommended Citation:
La Kim, E; Li, JL; Dang, HT; Hong, J; Lee, CO; Kim, DK; Yoon, WD; Kim, E; Liu, YH; Jung, JH.Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3126-3129
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[La Kim, E]'s Articles
[Li, JL]'s Articles
[Dang, HT]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[La Kim, E]‘s Articles
[Li, JL]‘s Articles
[Dang, HT]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace