Knowledge Management System Of South China Sea Institute of Oceanology,CAS
| Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai | |
| La Kim, E; Li, JL; Dang, HT; Hong, J; Lee, CO; Kim, DK; Yoon, WD; Kim, E; Liu, YH; Jung, JH; jhjung@pusan.ac.kr | |
| 2012 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| ISSN | 0960-894X |
| 卷号 | 22期号:9页码:3126-3129 |
| 摘要 | Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved. |
| 部门归属 | [La Kim, Eun; Li, Jian Lin; Dang, Hung The; Jung, Jee H.] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea; [Hong, Jongki] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea; [Lee, Chong-Ok] Korea Res Inst Chem Technol, Taejon 305343, South Korea; [Kim, Dong-Kyoo] Inje Univ, Dept Chem, Gimhae 621749, South Korea; [Yoon, Won Duk] Natl Fisheries Res & Dev Inst, Pusan 619705, South Korea; [Kim, Euikyung] Gyeongsang Natl Univ, Coll Vet Med, Jinju 660701, South Korea; [Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China |
| 关键词 | Cytochalasin Jellyfish-derived Fungus Phoma Sp. Nemopilema Nomurai Cytotoxicity |
| 学科领域 | Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| 资助项目 | LMB |
| WOS记录号 | WOS:000302964300017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.scsio.ac.cn/handle/344004/9924 |
| 专题 | 中科院海洋生物资源可持续利用重点实验室 |
| 通讯作者 | jhjung@pusan.ac.kr |
| 推荐引用方式 GB/T 7714 | La Kim, E,Li, JL,Dang, HT,et al. Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3126-3129. |
| APA | La Kim, E.,Li, JL.,Dang, HT.,Hong, J.,Lee, CO.,...&jhjung@pusan.ac.kr.(2012).Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3126-3129. |
| MLA | La Kim, E,et al."Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3126-3129. |
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