Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
La Kim, E; Li, JL; Dang, HT; Hong, J; Lee, CO; Kim, DK; Yoon, WD; Kim, E; Liu, YH; Jung, JH; jhjung@pusan.ac.kr
2012
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:9页码:3126-3129
摘要Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[La Kim, Eun; Li, Jian Lin; Dang, Hung The; Jung, Jee H.] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea; [Hong, Jongki] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea; [Lee, Chong-Ok] Korea Res Inst Chem Technol, Taejon 305343, South Korea; [Kim, Dong-Kyoo] Inje Univ, Dept Chem, Gimhae 621749, South Korea; [Yoon, Won Duk] Natl Fisheries Res & Dev Inst, Pusan 619705, South Korea; [Kim, Euikyung] Gyeongsang Natl Univ, Coll Vet Med, Jinju 660701, South Korea; [Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
关键词Cytochalasin Jellyfish-derived Fungus Phoma Sp. Nemopilema Nomurai Cytotoxicity
学科领域Chemistry, Medicinal ; Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000302964300017
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9924
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jhjung@pusan.ac.kr
推荐引用方式
GB/T 7714
La Kim, E,Li, JL,Dang, HT,et al. Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3126-3129.
APA La Kim, E.,Li, JL.,Dang, HT.,Hong, J.,Lee, CO.,...&jhjung@pusan.ac.kr.(2012).Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3126-3129.
MLA La Kim, E,et al."Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3126-3129.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Cytotoxic cytochalas(416KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。