[La Kim, Eun; Li, Jian Lin; Dang, Hung The; Jung, Jee H.] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea; [Hong, Jongki] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea; [Lee, Chong-Ok] Korea Res Inst Chem Technol, Taejon 305343, South Korea; [Kim, Dong-Kyoo] Inje Univ, Dept Chem, Gimhae 621749, South Korea; [Yoon, Won Duk] Natl Fisheries Res & Dev Inst, Pusan 619705, South Korea; [Kim, Euikyung] Gyeongsang Natl Univ, Coll Vet Med, Jinju 660701, South Korea; [Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China
项目归属:
LMB
摘要:
Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
La Kim, E; Li, JL; Dang, HT; Hong, J; Lee, CO; Kim, DK; Yoon, WD; Kim, E; Liu, YH; Jung, JH.Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3126-3129
