The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages
Chen, JH; Lan, XP; Liu, YH; Jia, AQ; yonghongliu@scsio.ac.cn; jiaaiqun@gmail.com
2012
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:9页码:3177-3180
摘要Diketopiperazines (DKPs) are a class of secondary metabolites that result from peptide bonds between two amino acids to form a lactam. Due to their rigid structure, chiral nature, and varied side chains, DKPs have been of research interest for their diverse bioactivities. However, little is known about whether DPKs stimulate the release of cytokine and chemokines in macrophage cells. The present aim was to study the effect of DKPs firstly isolated from sponge Callyspongia sp. on the release of several cytokines in murine macrophage-like cell line J774A.1 after stimulation in vitro, and their potential structure-activity relationship of five natural DKPs on four representative cytokines, interferon-gamma (IFN-gamma), pro-inflammatory (tumor necrosis factor, TNF-alpha), anti-inflammatory cytokine (interleukin-10, IL-10), and chemokine (monocyte chemoattractant protein-1, MCP-1). Results suggested that these five DKPs, especially DKP 1 bearing 3-hydroxyl-L-proline (L-Hyp), might be useful as a promising macrophage cytokines stimulator. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Lan, Xiang-Peng; Jia, Ai-Qun] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Jiangsu, Peoples R China; [Chen, Jin-Hui] Nanjing Forestry Univ, Minist Educ China, Key Lab Forest Genet & Biotechnol, Nanjing 210037, Jiangsu, Peoples R China
关键词Cytokine Chemokine Diketopiperazines J774a.1 Macrophage Structure-activity Relationships
学科领域Chemistry, Medicinal ; Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000302964300027
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9926
专题中科院海洋生物资源可持续利用重点实验室
通讯作者yonghongliu@scsio.ac.cn; jiaaiqun@gmail.com
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GB/T 7714
Chen, JH,Lan, XP,Liu, YH,et al. The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3177-3180.
APA Chen, JH,Lan, XP,Liu, YH,Jia, AQ,yonghongliu@scsio.ac.cn,&jiaaiqun@gmail.com.(2012).The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3177-3180.
MLA Chen, JH,et al."The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3177-3180.
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