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学科主题: Chemistry, Medicinal; Chemistry, Organic
题名: The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages
作者: Chen, JH ; Lan, XP ; Liu, YH ; Jia, AQ
通讯作者: yonghongliu@scsio.ac.cn ; jiaaiqun@gmail.com
关键词: Cytokine ; Chemokine ; Diketopiperazines ; J774A.1 macrophage ; Structure-activity relationships
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2012
卷: 22, 期:9, 页:3177-3180
部门归属: [Liu, Yonghong] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Lan, Xiang-Peng; Jia, Ai-Qun] Nanjing Univ Sci & Technol, Sch Environm & Biol Engn, Nanjing 210094, Jiangsu, Peoples R China; [Chen, Jin-Hui] Nanjing Forestry Univ, Minist Educ China, Key Lab Forest Genet & Biotechnol, Nanjing 210037, Jiangsu, Peoples R China
项目归属: LMB
摘要: Diketopiperazines (DKPs) are a class of secondary metabolites that result from peptide bonds between two amino acids to form a lactam. Due to their rigid structure, chiral nature, and varied side chains, DKPs have been of research interest for their diverse bioactivities. However, little is known about whether DPKs stimulate the release of cytokine and chemokines in macrophage cells. The present aim was to study the effect of DKPs firstly isolated from sponge Callyspongia sp. on the release of several cytokines in murine macrophage-like cell line J774A.1 after stimulation in vitro, and their potential structure-activity relationship of five natural DKPs on four representative cytokines, interferon-gamma (IFN-gamma), pro-inflammatory (tumor necrosis factor, TNF-alpha), anti-inflammatory cytokine (interleukin-10, IL-10), and chemokine (monocyte chemoattractant protein-1, MCP-1). Results suggested that these five DKPs, especially DKP 1 bearing 3-hydroxyl-L-proline (L-Hyp), might be useful as a promising macrophage cytokines stimulator. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000302964300027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9926
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Chen, JH; Lan, XP; Liu, YH; Jia, AQ.The effects of diketopiperazines from Callyspongia sp on release of cytokines and chemokines in cultured J774A.1 macrophages,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3177-3180
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