Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07
Chen, ZM; Zheng, ZH; Huang, HB; Song, YX; Zhang, XL; Ma, JY; Wang, B; Zhang, CS; Ju, JH; jju@scsio.ac.cn
2012
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号22期号:9页码:3332-3335
摘要Three new mycophenolic acid derivatives, penicacids A-C (1-3), together with two known analogues, mycophenolic acid (MPA, 4) and 4'-hydroxy-MPA (5), were isolated from a fungus Penicillium sp. SOF07 derived from a South China Sea marine sediment. The structures of compounds 1-3 were elucidated on the basis of MS and NMR (H-1, C-13, HSQC and HMBC) data analyses and comparisons with the known compounds. Structure-activity relationship studies of compounds 1-5 focused on inosine-monophosphate dehydrogenase inhibition revealed that hydroxylation at C-4', methylation at C-7-OH, dual hydroxylation at C-2'/C-3' double bond of MPA diminished bioactivity whereas glucosyl hydroxylation at C-4' correlated to bioactivity comparable to that observed for MPA. (C) 2012 Elsevier Ltd. All rights reserved.
部门归属[Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangzhou 510301, Guangdong, Peoples R China; [Zheng, Zhihui; Zhang, Xuelian] N China Pharmaceutial Grp Corp, Natl Microbial Med Engn & Res Ctr, New Drug Res Ctr, Shijiazhuang 050015, Peoples R China
关键词Marine Fungi Penicillium Sp. Penicacid A-c Inosine-monophosphate Dehydrogenase Structure-activity Relationship
学科领域Chemistry, Medicinal ; Chemistry, Organic
语种英语
资助项目LMB
WOS记录号WOS:000302964300059
引用统计
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9928
专题中科院海洋生物资源可持续利用重点实验室
通讯作者jju@scsio.ac.cn
推荐引用方式
GB/T 7714
Chen, ZM,Zheng, ZH,Huang, HB,et al. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3332-3335.
APA Chen, ZM.,Zheng, ZH.,Huang, HB.,Song, YX.,Zhang, XL.,...&jju@scsio.ac.cn.(2012).Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(9),3332-3335.
MLA Chen, ZM,et al."Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.9(2012):3332-3335.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。