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学科主题: Chemistry, Medicinal; Chemistry, Organic
题名: Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07
作者: Chen, ZM ; Zheng, ZH ; Huang, HB ; Song, YX ; Zhang, XL ; Ma, JY ; Wang, B ; Zhang, CS ; Ju, JH
通讯作者: jju@scsio.ac.cn
关键词: Marine fungi ; Penicillium sp. ; Penicacid A-C ; Inosine-monophosphate dehydrogenase ; Structure-activity relationship
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2012
卷: 22, 期:9, 页:3332-3335
部门归属: [Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Guangdong, Peoples R China; [Chen, Ziming; Huang, Hongbo; Song, Yongxiang; Ma, Junying; Wang, Bo; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangzhou 510301, Guangdong, Peoples R China; [Zheng, Zhihui; Zhang, Xuelian] N China Pharmaceutial Grp Corp, Natl Microbial Med Engn & Res Ctr, New Drug Res Ctr, Shijiazhuang 050015, Peoples R China
项目归属: LMB
摘要: Three new mycophenolic acid derivatives, penicacids A-C (1-3), together with two known analogues, mycophenolic acid (MPA, 4) and 4'-hydroxy-MPA (5), were isolated from a fungus Penicillium sp. SOF07 derived from a South China Sea marine sediment. The structures of compounds 1-3 were elucidated on the basis of MS and NMR (H-1, C-13, HSQC and HMBC) data analyses and comparisons with the known compounds. Structure-activity relationship studies of compounds 1-5 focused on inosine-monophosphate dehydrogenase inhibition revealed that hydroxylation at C-4', methylation at C-7-OH, dual hydroxylation at C-2'/C-3' double bond of MPA diminished bioactivity whereas glucosyl hydroxylation at C-4' correlated to bioactivity comparable to that observed for MPA. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000302964300059
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9928
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Chen, ZM; Zheng, ZH; Huang, HB; Song, YX; Zhang, XL; Ma, JY; Wang, B; Zhang, CS; Ju, JH.Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(9):3332-3335
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