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学科主题: Chemistry, Organic
题名: Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa
作者: Xu, Y ; Li, N ; Jiao, WH ; Wang, RP ; Peng, Y ; Qi, SH ; Song, SJ ; Chen, WS ; Lin, HW
通讯作者: songsj99@yahoo.com.cn ; frank-lin67@126.com
关键词: Acanthella cavernosa ; Kalihinol ; X-ray diffraction analysis ; Antifouling ; Cytotoxic ; Absolute configuration
刊名: TETRAHEDRON
发表日期: 2012
卷: 68, 期:13, 页:2876-2883
部门归属: [Xu, Ying; Li, Nan; Wang, Ru-Ping; Peng, Ying; Song, Shao-Jiang] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China; [Xu, Ying; Jiao, Wei-Hua; Wang, Ru-Ping; Chen, Wan-Sheng; Lin, Hou-Wen] Mil Med Coll 2, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China; [Qi, Shu-Hua] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: A bioassay-guided chemical investigation of the South China Sea sponge Acanthella cavemosa resulted in the isolation of eight new diterpenoids, kalihinols M-T (1-8), together with seven known analogues (9-15). These compounds featured a trans-decalin ring bearing a tetrahydrofuran or a tetrahydropyran ring at C-7. Compounds 1 and 2, with a formamide functionality beared at C-4, extended the structure breadth of this diterpenoid family. The absolute stereostructures of 1-14 were determined by a combination of 2D NMR and CD spectroscopic analysis and single crystal X-ray diffraction. Compounds 1 and 2 were confirmed to have the configurations of 4S, 55, whereas 3-14 were determined as 4R, 5R. Compounds 3-14 displayed significant antifouling activity against the barnacle Balanus amphitrite larvae, and the cytotoxic activities of 3-14 were evaluated against the H1299, A549, PC3, CT-26, and HCT-116 cancer cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
WOS记录号: WOS:000301964700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9952
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Xu, Y; Li, N; Jiao, WH; Wang, RP; Peng, Y; Qi, SH; Song, SJ; Chen, WS; Lin, HW.Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa,TETRAHEDRON,2012,68(13):2876-2883
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