SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室
Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa
Xu, Y; Li, N; Jiao, WH; Wang, RP; Peng, Y; Qi, SH; Song, SJ; Chen, WS; Lin, HW; songsj99@yahoo.com.cn; frank-lin67@126.com
2012
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume68Issue:13Pages:2876-2883
AbstractA bioassay-guided chemical investigation of the South China Sea sponge Acanthella cavemosa resulted in the isolation of eight new diterpenoids, kalihinols M-T (1-8), together with seven known analogues (9-15). These compounds featured a trans-decalin ring bearing a tetrahydrofuran or a tetrahydropyran ring at C-7. Compounds 1 and 2, with a formamide functionality beared at C-4, extended the structure breadth of this diterpenoid family. The absolute stereostructures of 1-14 were determined by a combination of 2D NMR and CD spectroscopic analysis and single crystal X-ray diffraction. Compounds 1 and 2 were confirmed to have the configurations of 4S, 55, whereas 3-14 were determined as 4R, 5R. Compounds 3-14 displayed significant antifouling activity against the barnacle Balanus amphitrite larvae, and the cytotoxic activities of 3-14 were evaluated against the H1299, A549, PC3, CT-26, and HCT-116 cancer cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
Department[Xu, Ying; Li, Nan; Wang, Ru-Ping; Peng, Ying; Song, Shao-Jiang] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China; [Xu, Ying; Jiao, Wei-Hua; Wang, Ru-Ping; Chen, Wan-Sheng; Lin, Hou-Wen] Mil Med Coll 2, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China; [Qi, Shu-Hua] Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
KeywordAcanthella Cavernosa Kalihinol X-ray Diffraction Analysis Antifouling Cytotoxic Absolute Configuration
Subject AreaChemistry, Organic
Language英语
Funding ProjectLMB
WOS IDWOS:000301964700016
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/9952
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authorsongsj99@yahoo.com.cn; frank-lin67@126.com
Recommended Citation
GB/T 7714
Xu, Y,Li, N,Jiao, WH,et al. Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa[J]. TETRAHEDRON,2012,68(13):2876-2883.
APA Xu, Y.,Li, N.,Jiao, WH.,Wang, RP.,Peng, Y.,...&frank-lin67@126.com.(2012).Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa.TETRAHEDRON,68(13),2876-2883.
MLA Xu, Y,et al."Antifouling and cytotoxic constituents from the South China Sea sponge Acanthella cavernosa".TETRAHEDRON 68.13(2012):2876-2883.
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