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学科主题: Chemistry, Medicinal
题名: Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus
作者: Han, Z ; Xu, Y ; McConnell, O ; Liu, LL ; Li, YX ; Qi, SH ; Huang, XZ ; Qian, PY
通讯作者: zhuanghan@ust.hk ; boxuying@ust.hk ; oliver.mcconnell@johnihaas.com ; leonie@ust.hk ; liyongxing@ust.hk ; shuhuaqi@scsio.ac.cn ; xiangzhonghuang@yahoo.com.cn ; boqianpy@ust.hk
关键词: marine-derived actinomycete ; Streptomyces lusitanus ; antibacterial ; antimycin B
刊名: MARINE DRUGS
发表日期: 2012
卷: 10, 期:3, 页:668-676
部门归属: [Han, Zhuang; Xu, Ying; Liu, Lingli; Li, Yongxin; Huang, Xiangzhong; Qian, Peiyuan] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China; [Han, Zhuang; Qi, Shuhua] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,S China Sea Inst, Guangzhou 510301, Guangdong, Peoples R China; [Han, Zhuang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [McConnell, Oliver] John I Haas Inc, Yakima, WA 98902 USA
项目归属: LMB
摘要: Two new antimycin A analogues, antimycin B1 and B2 (1-2), were isolated from a spent broth of a marine-derived bacterium, Streptomyces lusitanus. The structures of 1 and 2 were established on the basis of spectroscopic analyses and chemical methods. The isolated compounds were tested for their anti-bacterial potency. Compound 1 was found to be inactive against the bacteria Bacillus subtilis, Staphyloccocus aureus, and Loktanella hongkongensis. Compound 2 showed antibacterial activities against S. aureus and L. hongkongensis with MIC values of 32.0 and 8.0 mu g/mL, respectively.
语种: 英语
WOS记录号: WOS:000302136700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9964
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Han, Z; Xu, Y; McConnell, O; Liu, LL; Li, YX; Qi, SH; Huang, XZ; Qian, PY.Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus,MARINE DRUGS,2012,10(3):668-676
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