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Selection pressure drives the co-evolution of several lipid metabolism genes in mammals
Lin, BF; Yuan, LH; Chen, JP; yuanlh@gdei.gd.cn
2012
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume57Issue:8Pages:877-885
AbstractAdipose tissue is an important endocrine organ and energy supplier. Its physiological effect on the regulation of the energy balance is considered an important factor underlying the evolution of mammals. To test whether the genes controlling lipid metabolism have undergone adaptive molecular change in the evolution of mammals, in this study, we used the orthologous gene sequences of 12 important lipid metabolism proteins (leptin, OB-RL, RXRA, RXRB, RXRG, PPARA, PPARB/D, PPARG, PNLIP, ADIPOQ, LPL and UCP1) from NCBI's databases. We found evidence that 4 of the corresponding genes (leptin, ADIPOQ, PNLIP and PPARA) have undergone positive selection in their evolutionary history and that most adaptive changes occurred during the evolution of the super-clades Laurasiatheria (placentals) and suborders within Euarchontoglires (primates and rodents). Comparisons across sets of genes showed that in a third of cases, bursts of positive selection, more than would be expected by chance, occurred on corresponding branches. We propose that the positive selection drives adaptive changes in some lipid metabolism genes in or within Laurasiatheria and Euarchontoglires clades. Along with evidence from earlier studies, our results show that co-evolution among interacting lipid metabolism proteins has taken place.
Department[Lin BenFu; Yuan LiHong; Chen JinPing] S China Inst Endangered Anim, Guangzhou 510260, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, S China Sea Inst Oceanol, Chinese Acad Sci LAMB, Guangzhou 510301, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Procince, Guangzhou 510301, Guangdong, Peoples R China
KeywordProtein Evolution Lipid Metabolism Darwinian Selection Positive Selection
Subject AreaMultidisciplinary Sciences
Language英语
Funding ProjectLMB
WOS IDWOS:000300771400008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.scsio.ac.cn/handle/344004/9970
Collection中科院海洋生物资源可持续利用重点实验室
Corresponding Authoryuanlh@gdei.gd.cn
Recommended Citation
GB/T 7714
Lin, BF,Yuan, LH,Chen, JP,et al. Selection pressure drives the co-evolution of several lipid metabolism genes in mammals[J]. CHINESE SCIENCE BULLETIN,2012,57(8):877-885.
APA Lin, BF,Yuan, LH,Chen, JP,&yuanlh@gdei.gd.cn.(2012).Selection pressure drives the co-evolution of several lipid metabolism genes in mammals.CHINESE SCIENCE BULLETIN,57(8),877-885.
MLA Lin, BF,et al."Selection pressure drives the co-evolution of several lipid metabolism genes in mammals".CHINESE SCIENCE BULLETIN 57.8(2012):877-885.
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