中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Multidisciplinary Sciences
题名: Selection pressure drives the co-evolution of several lipid metabolism genes in mammals
作者: Lin, BF ; Yuan, LH ; Chen, JP
通讯作者: yuanlh@gdei.gd.cn
关键词: protein evolution ; lipid metabolism ; Darwinian selection ; positive selection
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2012
卷: 57, 期:8, 页:877-885
部门归属: [Lin BenFu; Yuan LiHong; Chen JinPing] S China Inst Endangered Anim, Guangzhou 510260, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, S China Sea Inst Oceanol, Chinese Acad Sci LAMB, Guangzhou 510301, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China; [Yuan LiHong; Chen JinPing] Chinese Acad Sci, Key Lab Appl Marine Biol Guangdong Procince, Guangzhou 510301, Guangdong, Peoples R China
项目归属: LMB
摘要: Adipose tissue is an important endocrine organ and energy supplier. Its physiological effect on the regulation of the energy balance is considered an important factor underlying the evolution of mammals. To test whether the genes controlling lipid metabolism have undergone adaptive molecular change in the evolution of mammals, in this study, we used the orthologous gene sequences of 12 important lipid metabolism proteins (leptin, OB-RL, RXRA, RXRB, RXRG, PPARA, PPARB/D, PPARG, PNLIP, ADIPOQ, LPL and UCP1) from NCBI's databases. We found evidence that 4 of the corresponding genes (leptin, ADIPOQ, PNLIP and PPARA) have undergone positive selection in their evolutionary history and that most adaptive changes occurred during the evolution of the super-clades Laurasiatheria (placentals) and suborders within Euarchontoglires (primates and rodents). Comparisons across sets of genes showed that in a third of cases, bursts of positive selection, more than would be expected by chance, occurred on corresponding branches. We propose that the positive selection drives adaptive changes in some lipid metabolism genes in or within Laurasiatheria and Euarchontoglires clades. Along with evidence from earlier studies, our results show that co-evolution among interacting lipid metabolism proteins has taken place.
语种: 英语
WOS记录号: WOS:000300771400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9970
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Selection pressure drives the co-evolution of several lipid metabolism genes in mammals.pdf(883KB)----开放获取--View Download

Recommended Citation:
Lin, BF; Yuan, LH; Chen, JP.Selection pressure drives the co-evolution of several lipid metabolism genes in mammals,CHINESE SCIENCE BULLETIN,2012,57(8):877-885
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lin, BF]'s Articles
[Yuan, LH]'s Articles
[Chen, JP]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lin, BF]‘s Articles
[Yuan, LH]‘s Articles
[Chen, JP]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Selection pressure drives the co-evolution of several lipid metabolism genes in mammals.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院南海海洋研究所 - Feedback
Powered by CSpace