中国科学院南海海洋研究所机构知识库
Advanced  
SCSIO OpenIR  > 中科院海洋生物资源可持续利用重点实验室  > 期刊论文
学科主题: Chemistry, Multidisciplinary
题名: Delta(11,12) Double Bond Formation in Tirandamycin Biosynthesis is Atypically Catalyzed by TrdE, a Glycoside Hydrolase Family Enzyme
作者: Mo, XH ; Ma, JY ; Huang, HB ; Wang, B ; Song, YD ; Zhang, S ; Zhang, CS ; Ju, JH
通讯作者: jju@scsio.ac.cn
刊名: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
发表日期: 2012
卷: 134, 期:6, 页:2844-2847
部门归属: [Mo, Xuhua; Ma, Junying; Huang, Hongbo; Wang, Bo; Song, Yongdang; Zhang, Si; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, S China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guandong Key Lab Marine, CAS Key Lab Marine Bioresources Sustainable Utili, Guangzhou 510301, Guangdong, Peoples R China; [Mo, Xuhua] Chinese Acad Sci, Grad Univ, Beijing 110039, Peoples R China
项目归属: LMB
摘要: The tirandamycins (TAMs) are a small group of Streptomyces-derived natural products that target bacterial RNA polymerase. Within the TAM biosynthetic cluster, trdE encodes a glycoside hydrolase whose role in TAM biosynthesis has been undefined until now. We report that in vivo trdE inactivation leads to accumulation of pre-tirandamycin, the earliest intermediate released from its mixed polyketide/nonribosomal peptide biosynthetic assembly line. In vitro and site-directed mutagenesis studies showed that TrdE, a putative glycoside hydrolase, catalyzes in a highly atypical fashion the installation of the Delta(11,12) double bond during TAM biosynthesis.
语种: 英语
WOS记录号: WOS:000301161500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9974
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

Files in This Item:

There are no files associated with this item.


Recommended Citation:
Mo, XH; Ma, JY; Huang, HB; Wang, B; Song, YD; Zhang, S; Zhang, CS; Ju, JH.Delta(11,12) Double Bond Formation in Tirandamycin Biosynthesis is Atypically Catalyzed by TrdE, a Glycoside Hydrolase Family Enzyme,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2012,134(6):2844-2847
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mo, XH]'s Articles
[Ma, JY]'s Articles
[Huang, HB]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mo, XH]‘s Articles
[Ma, JY]‘s Articles
[Huang, HB]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院南海海洋研究所 - Feedback
Powered by CSpace