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学科主题: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
题名: Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32
作者: Huang, HB ; Yang, TT ; Ren, XM ; Liu, J ; Song, YX ; Sun, AJ ; Ma, JY ; Wang, B ; Zhang, Y ; Huang, CG ; Zhang, CS ; Ju, JH
通讯作者: jju@scsio.ac.cn
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2012
卷: 75, 期:2, 页:202-208
部门归属: [Huang, Hongbo; Ren, Xiangmei; Liu, Jing; Song, Yongxiang; Sun, Aijun; Ma, Junying; Wang, Bo; Zhang, Yun; Zhang, Changsheng; Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Yang, Tingting; Huang, Caiguo] Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China; [Ren, Xiangmei; Liu, Jing; Zhang, Yun] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
项目归属: LMB
摘要: Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and ID and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC50 values ranging from 1.1 to 31 mu M.
语种: 英语
WOS记录号: WOS:000300601500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.scsio.ac.cn/handle/344004/9978
Appears in Collections:中科院海洋生物资源可持续利用重点实验室_期刊论文

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Recommended Citation:
Huang, HB; Yang, TT; Ren, XM; Liu, J; Song, YX; Sun, AJ; Ma, JY; Wang, B; Zhang, Y; Huang, CG; Zhang, CS; Ju, JH.Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32,JOURNAL OF NATURAL PRODUCTS,2012,75(2):202-208
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文件名: Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32.pdf
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