Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp BL321
Song, YX; Wang, JJ; Huang, HB; Ma, L; Wang, J; Gu, YC; Liu, L; Lin, YC; songxiang0517@126.com; kakinvono@gmail.com; huanghb@scsio.ac.cn; cesmal@mail.sysu.edu.cn; wjun@mail.sysu.edu.cn; yucheng.gu@syngenta.com; cesllan@mail.sysu.edu.cn; ceslyc@mail.sysu.edu.cn
2012
发表期刊MARINE DRUGS
ISSN1660-3397
卷号10期号:2页码:340-348
摘要Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on alpha-glucosidase at 0.15 mu M (146%), and then, 4 gradually produced inhibitory activity on alpha-glucosidase with increasing concentration, and the IC50 value is 6.54 mu M.
部门归属[Song, Yongxiang; Wang, Jiajian; Huang, Hongbo; Ma, Lin; Liu, Lan; Lin, Yongcheng] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China; [Song, Yongxiang; Huang, Hongbo] Chinese Acad Sci, CAS Key Lab Marine Bioresources Sustainable Utili, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,S China Sea Inst Oceano, Guangzhou 510301, Guangdong, Peoples R China; [Wang, Jun; Liu, Lan; Lin, Yongcheng] Sun Yat Sen Univ, Guangdong Prov Key Lab Funct Mol Ocean Microorgan, Bur Educ Guangdong, Guangzhou 510275, Guangdong, Peoples R China; [Wang, Jun] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510080, Guangdong, Peoples R China; [Gu, Yucheng] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
关键词Marine Fungus Xylaria Sp. Mangrove Sesquiterpenes Alpha-glucosidase
学科领域Chemistry, Medicinal
语种英语
资助项目LMB
WOS记录号WOS:000300716000006
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.scsio.ac.cn/handle/344004/9980
专题中科院海洋生物资源可持续利用重点实验室
通讯作者songxiang0517@126.com; kakinvono@gmail.com; huanghb@scsio.ac.cn; cesmal@mail.sysu.edu.cn; wjun@mail.sysu.edu.cn; yucheng.gu@syngenta.com; cesllan@mail.sysu.edu.cn; ceslyc@mail.sysu.edu.cn
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Song, YX,Wang, JJ,Huang, HB,et al. Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp BL321[J]. MARINE DRUGS,2012,10(2):340-348.
APA Song, YX.,Wang, JJ.,Huang, HB.,Ma, L.,Wang, J.,...&ceslyc@mail.sysu.edu.cn.(2012).Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp BL321.MARINE DRUGS,10(2),340-348.
MLA Song, YX,et al."Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp BL321".MARINE DRUGS 10.2(2012):340-348.
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