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Proximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived Verrucosispora sp. SCSIO 40062 by Overexpression of PPtase Genes 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2020, 卷号: 83, 期号: 4, 页码: 1152, 1156
Authors:  Fang, Chunyan;  Zhang, Qingbo;  Zhu, Yiguang;  Zhang, Liping;  Zhang, Wenjun;  Ma, Liang;  Zhang, Haibo;  Zhang, Changsheng
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Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 14, 页码: 4709, 4722
Authors:  Manenda, Mahder S.;  Picard, Marie-Eve;  Zhang, Liping;  Cyr, Normand;  Zhu, Xiaojun;  Barma, Julie;  Pascal, John M.;  Couture, Manon;  Zhang, Changsheng;  Shi, Rong
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flavin adenine dinucleotide (FAD)  enzyme catalysis  enzyme mechanism  small-angle X-ray scattering (SAXS)  crystal structure  flavin-dependent monooxygenase  hydroxylation  mobile flavin  piericidin  sliding conformation  
Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis 期刊论文
ORGANIC LETTERS, 2020, 卷号: 22, 期号: 5, 页码: 1731, 1735
Authors:  Jin, Hongbo;  Zhang, Wenjun;  Zhang, Guangtao;  Zhang, Liping;  Liu, Wei;  Zhang, Changsheng
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Heterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible Glycosyltransferase 期刊论文
ORGANIC LETTERS, 2020, 卷号: 22, 期号: 3, 页码: 1062, 1066
Authors:  Tan, Bin;  Chen, Siqiang;  Zhang, Qingbo;  Chen, Yuchan;  Zhu, Yiguang;  Khan, Imran;  Zhang, Weimin;  Zhang, Changsheng
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Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 卷号: 18, 期号: 19, 页码: 3649, 3653
Authors:  Liu, Wei;  Jannu, Vinay Gopal;  Liu, Zhiwen;  Zhang, Qingbo;  Jiang, Xiaodong;  Ma, Liang;  Zhang, Wenjun;  Zhang, Changsheng;  Zhu, Yiguang
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Activation and Characterization of Bohemamine Biosynthetic Gene Cluster from Streptomyces sp. CB02009 期刊论文
ORGANIC LETTERS, 2020, 卷号: 22, 期号: 12, 页码: 4614, 4619
Authors:  Liu, Ling;  Li, Sainan;  Sun, Runze;  Qin, Xiangjing;  Ju, Jianhua;  Zhang, Changsheng;  Duan, Yanwen;  Huang, Yong
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Understand the Specific Regio- and Enantioselectivity of Fluostatin Conjugation in the Post-Biosynthesis 期刊论文
BIOMOLECULES, 2020, 卷号: 10, 期号: 6, 页码: 815
Authors:  Wang, Yuanqi;  Zhang, Changsheng;  Zhao, Yi-Lei;  Zhao, Rosalinda;  Houk, Kendall N.
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fluostatin  conjugation  regioselectivity  stereoselectivity  pi-pi stacking interaction  
Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019 期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 35, 页码: 20738, 20744
Authors:  Khan, Imran;  Zhang, Haibo;  Liu, Wei;  Zhang, Liping;  Peng, Fang;  Chen, Yuchan;  Zhang, Qingbo;  Zhang, Guangtao;  Zhang, Weimin;  Zhang, Changsheng
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Refactoring the Concise Biosynthetic Pathway of Cyanogramide Unveils Spirooxindole Formation Catalyzed by a P450 Enzyme 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59, 期号: 33, 页码: 14065, 14069
Authors:  Zhu, Yiguang;  Zhang, Qingbo;  Fang, Chunyan;  Zhang, Yingli;  Ma, Liang;  Liu, Zhiwen;  Zhai, Shilan;  Peng, Jing;  Zhang, Liping;  Zhu, Weiming;  Zhang, Changsheng
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alkaloids  biosynthesis  cyanogramide  heterologous expression  spirooxindoles  
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites 期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 7, 页码: 1228, 1238
Authors:  Kang, Sisi;  Yang, Mei;  Hong, Zhongsi;  Zhang, Liping;  Huang, Zhaoxia;  Chen, Xiaoxue;  He, Suhua;  Zhou, Ziliang;  Zhou, Zhechong;  Chen, Qiuyue;  Yan, Yan;  Zhang, Changsheng;  Shan, Hong;  Chen, Shoudeng
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COVID-19  Coronavirus  SARS-CoV-2  Nucleocapsid protein  RNA binding domain  Crystal structure  Antiviral targeting site